bta-mir-339a: Bta-mir-339a is a microRNA that is targeted in the BCL gene family members [PMC7541945]. It was identified as one of the eight miRNAs with functions related to mastitis in an analysis of the RNA-Seq dataset [PMC8928958]. The target genes of bta-mir-339a were found to be enriched for 10 significant pathways, including the MAPK signaling pathway [PMC6637853]. Differential hubbing analysis revealed that bta-mir-339a is one of the top five negative regulators, with more connections in a specific group [PMC6637853]. Bta-mir-339a and FRAT1 were identified as top negatively hubbed genes for OA, associated with glycogen synthase kinase-3 binding protein and Wnt signaling pathway [PMC6637853]. In bovine mammary epithelial cell culture, bta-mir-339a was negatively associated with lactogenic differentiation [PMC10000098]. The target genes of bta-mir-339a were found to be enriched for 10 significant pathways, including the MAPK signaling pathway [PMC10000098]. In healthy cows compared to at-risk cows, bta-mir-339a was downregulated in both H_ARM and H_SCM pairwise comparisons [PMC10000098]. References: [PMC7541945] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541945/ [PMC8928958] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928958/ [PMC6637853] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637853/ [PM10000098] - https://www.ncbi.nlm.nih.gov/pmc/articles/PM10000098/