hsa-mir-3940: Hsa-mir-3940 is a small non-coding RNA, approximately 19-24 nucleotides in length, that has been implicated in various biological processes, particularly in cancer [5] [6]. Aberrant expression of miRNAs, including hsa-mir-3940, has been associated with cancer diagnosis and prognosis [6]. In the tumor microenvironment (TME), miRNAs like hsa-mir-3940 regulate the growth and proliferation of immune and stromal cells [7]. In colorectal cancer (CRC), serum hsa-miRNA-3940-5p has been identified as an independent prognostic factor [8]. Additionally, a miRNA index (miR.index) that includes hsa-mir-3940 and eight other miRNAs has been shown to be an independent predictor of survival in patients with lung adenocarcinoma (LUAD) [9]. However, the specific role of hsa-mir-3940-5p in LUAD is not yet well understood [10]. Hsa-mir-3940 is one of the seven human and mouse mirtron entries found in the MirGeneDB database [11]. Furthermore, two novel seed sequence indels have been identified in hsa-mir-4483 and hsa-mir-3940 at specific chromosomal locations [12]. In a study comparing smokers to non-smokers, lower levels of hsa-miR-296–5p, hsa-mir-3940, and hsa-miR520d3p were observed in smokers [13]. Hsa-mir 3940 has recently been annotated as a miRNA expressed at low levels in various mouse tissues including cardiac tissue [14]. Additionally, it has been included as one of nine miRNAs used to construct a prognostic model for LUAD patients [15]. This suggests that miR-3940-3p may serve as a potential indicator for the survival of LUAD patients [16].