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hsa-mir-377: Hsa-mir-377 is a microRNA that has been identified as a potential prognostic marker in various diseases, including cancer and diabetes [PMC9891867]. It has been found to be upregulated in response to PKCĪµ activation, leading to downregulation of ADAMTS5 and a reduction in cleaved aggrecan in NP cells ECM [PMC3842981]. Hsa-mir-377 has also been implicated in tumour development, suggesting a potential role in cancer progression [PMC9891867]. Additionally, it has been identified as one of the differentially expressed miRNAs in PC3 cells [PMC6874298]. Furthermore, hsa-mir-377 has been validated as one of the miRNAs that can be predicted using training data unrelated to the original dataset [PMC1159118].
References:
- [PMC9891867]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891867/
- [PMC3842981]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842981/
- [PMC6874298]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874298/
- [PMC1159118]: https://pubmed.ncbi.nlm.nih.gov/1159118/
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