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Homo sapiens (human) testis expressed transcript, Y-linked 10 (TTTY10) URS000007C6F9_9606

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TTTY10: TTTY10 is a testes-specific gene that has been identified as a potential prognostic biomarker for predicting recurrence in patients with papillary thyroid carcinoma (PTC) [PMC6857915] [PMC8383148]. It is one of several Y-linked genes that have been found to display low expression in samples from fertile patients and high expression in samples from infertile patients [PMC6375207]. TTTY10 has also been implicated in COVID-19, as it was found to be downregulated in male patients with the disease [PMC9150012]. Additionally, TTTY10 has been identified as a potential prognostic marker for predicting tumor recurrence in PTC and has been included in a lncRNA signature for this purpose [PMC8548639] [PMC7417634]. It is involved in various cellular processes, including cell attachment, transcription, signal conduction, growth, and differentiation through its interaction with the FoxO1 gene [PMC9259367]. TTTY10 has also been associated with fertility issues, as it is located within the AZFb region of the Y chromosome that is associated with microdeletions linked to infertility [PMC9023810]. Furthermore, TTTY10 has been found to be differentially expressed between males and females and may have implications for cardiovascular disease and colorectal cancer progression [PMC7022900] [PMC5553992]. Overall, TTTY10 appears to have diverse roles and may serve as a potential biomarker or therapeutic target in various diseases.

Genome locations

Gene Ontology annotations

Sequence

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AGGGCAGUGAACCUAAGCCAGGAGCUGCUUAGGCAUUAAGGCUUCUAUACCCAGAAUCGUGUGCUAAGCUUUCUCUCCAAGUCAGCACAACAAAGCAAACCAGAGCAUCGUACCAACAACCUGAAAGGUCACCUGACUCCUUCCUUCUCACUCCCAUUCUGUACUUCUGCAUACGUGGGCAGGCAAGUGAAUGGUAAGUAAGCCUGCAAACAGCCUUUCUUUGUAUAGGGAAUGACAGGCAUUUCAUCAGCAACUCCAGGAUGGCAGGCCGUUAUCCUGAAACCUAUCAGAACAGCUCCUGCUUGGCUUCCAAAAUAUCACAAUUUUGGAAAUGUACAAAGGUUAGUUUUCACAGUCCUUGAAGCCUCUUUCCACCCUGGCCAUAGCCCAUGUCAGCAGUAACCUAUGUCUUUGUUUUACAUAUCAUGUUGUUUUACUCACCUGGUGCCUCCAGUGCCCUAUAGGGUCCCUGAGCUGUCCUGAUACUCUUUCUUAGAUCCUGUCAAAACACUCACUUCAACAAAUUCUGCCCUUGGACUCUGAUGGGAGGUUCUGAUAAAGAAAAUUAUUGAAAACCGCAUUAUUUAAAUGUGGUUAUAUUUCAGCUGGACCUGGAAAUAAAGACGAAAUACUGCUUCGUGACUGUGCUUUAAGGAAUUUUUGCUUCUAGGAGAUGAUUGUGAGCCAGGCAGAGGUGAAGGAGCAGGAGCAAAUAGCCAAGGCACAGUUCACAGUGCUGGAUUUUCUUGUGGAUAUAGCUGCAUUGUUGUUCCUUCUGCCUUGUCCAACUGCUUCCUGGUAUCCCUACCCUCACCUUUUCGUUAUCUUUUCAUCUCUCUAAUCAUUGAGAAAAAGAGUACAAAAAGCCAGAUUUUGCAGUUCCCUAUUUUGUAUUCCAGGUUGAAGAGUGCUCUGGCUGUAGAGGGUCCCCACGAUCUGUCAUCUAGUAACUCACCAGAUACAUAAGAUAUUUUGCCUGCUAUGAAGCCAUUGGAGAAUCAGGUCCAGCUGUGUCCUACAGAUUUAUACCCUCACUUUGGAUGCACUGUGAAUCUUGAAACAAUUCAUUUUAUACUUAACCCUUUAAGUAUAAAGUAUAUACUUCAAGUAUAAAGUGUAAGGUUGCUUCAUUUCAUGGGCCCACCCAGGAUUUAAAGGUGUAUUCCCUGAAAGAAUUGGUUCCUUCCGGUGGGUUCCUGGCUGACUUCAAGAAUGAAGCUGCAGACACUUAUGGACUGGGAGGAGGCCCACGAGAAAAACAGGAAGAACAAGAGAAAGGCUGAGGCUCUAGUGGCUGCUUUGCAGACUUGCAGAGUCCAGGAUCCCCCAGGAACUUCCACUGAUUGCUACCUGUUACCAGUGUUAAAGCCAGGGCACUUUAAGAAGAAUUGCCCAAGCCACAAGAAAAAGCCACCUUGACCACUUUUGUGGUGAAGACCACUGGAGAUUGCACUACUGACCACCAAGACAGAGACACAAUAGCGAAUCUAGAAGUGGAAGUGUGAGAGAUACCUGCAGCUGUUAAGAUGUCUGGGAAUAGACACACAAACUCUCUCUCCCAGAUAAGCAACACAAAGCAGCACAGAGCAACAGAGACUGAAAGUCUGCCUACCUGAUCAGGGAAUAAG

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