MIR876: MIR876 is a gene that encodes two MicroRNAs, miR-876-3p and miR-876-5p [PMC3210160]. A bivariate GWAS study was conducted in Chinese and US Caucasians, focusing on femoral neck bone geometry and body lean mass, which are major risk factors for musculoskeletal disease [PMC3706967]. In Chinese individuals, MIR876 was found to be associated with bone geometry and ALM (appendicular lean mass), but these associations were not replicated in Caucasians [PMC3210160]. A group of 11 contiguous SNPs located within genomic regions containing MIR876 and MIR873 were strongly associated with ALM-BR (appendicular lean mass to body ratio) in Chinese individuals [PMC3210160]. The exact mechanisms by which MIR876 and MIR873 are involved in co-regulating bone and muscle metabolism remain unclear [PMC3210160]. In a bivariate GWAS for ALM and femoral neck bone geometry, 13 SNPs located within or near HK2, UMOD, MIR876, and MIR873 showed strong associations with both traits [PMC3210160]. Two of these SNPs were located in the promoter region of the MIR876 gene [PMC3210160]. Methylation-sensitive microRNAs including miR27A, miR-193a-5p (MIR193A), and miR-876-3p (MIR876) were also identified in the study [PMC9582525]. Additionally, pGBMs (primary glioblastomas) often exhibit a recurrent deletion on chromosome 9p21.3 that includes the MIR876 gene [PMC6388501].
Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset
View annotations in different species by clicking on species names.
Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.