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Homo sapiens (human) WNT signaling pathway activating non-coding RNA (WSPAR) URS000006CB8E_9606

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WSPAR: WSPAR, also known as lncTCF7, is a cancer-relevant long non-coding RNA (lncRNA) that is involved in the WNT signaling pathway [PMC6801803]. It has been reported to promote aggressiveness in hepatocellular carcinoma through epithelial-mesenchymal transition [PMC7382032]. The significance of WSPAR, along with other ncRNAs such as has-miR-4425, has-miR-4536-5p, and has-miR-410-5p, in pancreatic cancer prognosis has been investigated [PMC7382032]. The biological functions and molecular mechanisms of factors like HCAR3, PPY, RFWD2, WSPAR, and Amcinonide should be further studied to facilitate translational research in pancreatic cancer [PMC7382032]. WSPAR is transcribed 200 kb upstream of TCF7 and can activate TCF7 expression and the WNT signaling pathway by recruiting SWI/SNF to the TCF7 promoter [PMC4894931]. In hepatocellular carcinoma cells, WSPAR is highly expressed and activates expression of members of the Tcf/Lef family [PMC8987526]. Experimental assays have used MYC as a positive control and WSPAR as a negative control [PMC9662857].

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