hsa-mir-527: Hsa-mir-527 is a placental microRNA that has been found to be significantly elevated in the sera of third trimester pregnant women, with levels increased by more than 600 fold [PMC2519789]. It has also been detected in HCC cell lines and tumor tissues, where its expression was found to be significantly affected by miR-527 inhibition and mimic groups [PMC8489137]. Hsa-mir-527 has been shown to be negatively regulated by hsa_circ_0001306, as indicated by experimental results [PMC8489137]. However, hsa-mir-527 could not be enriched by the circPOFUT1 probe in a study analyzing RNA enrichment [PMC9829716]. In the context of EZH2-related sub-networks, hsa-mir-527 is one of three miRNAs that interact with EZH2 and may have potential inhibitory effects on its oncogenic function [PMC9148400]. Hsa-mir-527 is also one of several miRNAs that have been found to have anti-correlated mRNA levels for certain genes in specific cancer types [PMC4175465]. It has been proposed as an exosomal biomarker for exposure of HEK293 cells to PbS-MPA [PMC4560511]. In addition, hsa-mir-527 has been identified as one of the miRNAs negatively and significantly correlated with age in a study analyzing age-related changes in miRNA expression [PMC10126023]. It was also identified as one of the hub genes and transcription factors driving GBM tumorigenicity based on enrichment analysis [PMC6180049].