gga-mir-30d: gga-mir-30d is a microRNA (miRNA) encoded by chicken chromosome 2 and belongs to the miR-30 family [PMC7125550]. Research has demonstrated that gga-mir-30d has the ability to inhibit the replication of Infectious Bronchitis Virus (IBV) by targeting a specific protein called ubiquitin-specific peptidase 47 (USP47) in HD11 cells [PMC8779696]. This finding suggests that gga-mir-30d plays a crucial role in the immune response against IBV infection. MicroRNAs are small non-coding RNA molecules that regulate gene expression by binding to specific messenger RNA (mRNA) molecules and preventing their translation into proteins [PMC7125550]. The miR-30 family is known to be involved in various biological processes, including cell proliferation, differentiation, and apoptosis [PMC7125550]. In the context of IBV infection, gga-mir-30d has been identified as a key player in inhibiting viral replication. The mechanism of action involves targeting USP47, which is an enzyme involved in protein degradation and immune response regulation [PMC8779696]. By targeting USP47, gga-mir-30d can potentially disrupt viral replication and enhance the host's defense against IBV. These findings highlight the importance of gga-mir-30d as a potential therapeutic target for controlling IBV infection. Further research is needed to fully understand the regulatory mechanisms of gga-mir-30d and its potential applications in antiviral strategies.