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hsa-mir-1248: Hsa-mir-1248 is a miRNA that is considered an oncomiR [PMC7277914]. It has been found to bind to the 3′UTR of the BRCA1 gene, along with hsa-mir-4278 [PMC7277914]. Additionally, the creation of miRNA family binding sites, such as hsa-miR-548, has been observed in the BRCA2 gene [PMC7277914]. The antitumor effect of hsa-mir-1248 can be influenced by the expression of PSMD10, with its suppression or enhancement being achieved by up-regulating or down-regulating PSMD10 expression [PMC9414407]. These findings suggest that hsa-mir-1248 and its interactions with BRCA1 and PSMD10 may play a role in tumorigenesis and tumor suppression. Further research is needed to fully understand the mechanisms and implications of these interactions.
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