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Homo sapiens (human) small nucleolar RNA, H/ACA box 59A (SNORA59A, SNORA59B) secondary structure diagram

Homo sapiens (human) small nucleolar RNA, H/ACA box 59A (SNORA59A, SNORA59B) URS0000056589_9606

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SNORA59A: SNORA59A is a small nucleolar RNA (snoRNA) that has been detected in both control and osteoarthritic samples [PMC10094766]. It has been implicated in prostate cancer [PMC8649667] and renal clear cell carcinoma [PMC10050728]. SNORA59A is one of the snoRNAs that play a role in the development of clear cell renal cell carcinoma (ccRCC) and may serve as a diagnostic biomarker for ccRCC patients [PMC7812721]. It has also been identified as a risk factor for tumor metastasis and progression in hepatocellular carcinoma (HCC) [PMC9524901]. SNORA59A is one of the snoRNAs that are significantly related to the prognosis of HCC, and its expression is correlated with neutrophil infiltration [PMC9524901]. The expression of SNORA59A has also been found to be related to Th2 cells and Th17 cells infiltration levels [PMC9524901]. Hypermethylation of CpG islands near the 5'-termini of host genes for SNORA59A has been observed in cancer cells, suggesting its potential role as a specific marker for cancer cells compared to normal human cells [PMC4427830]. The host gene-associated 5'CpG islands of SNORA59A have also been found to be hypermethylated in colorectal cancer cells [PMC7011154]. In summary, SNORA59A is an important snoRNA with potential diagnostic, prognostic, and therapeutic implications in various types of cancer.

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2D structure Publications