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Homo sapiens (human) hsa-miR-483-5p URS000003575B_9606

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hsa-mir-483: Hsa-mir-483 is a miRNA precursor located in intron 2 of the short isoform of the IGF2 gene [PMC2788396]. In a study comparing plasma samples of Down syndrome (DS) patients and healthy control subjects, hsa-mir-483 was found to be downregulated in DS patients [PMC6382869]. Additionally, hsa-mir-483 was found to be upregulated in subgroup 2, which correlated with decreased survival probability [PMC6448130]. Hsa-mir-483 has been implicated in various types of cancers, including pancreatic, lung, bladder, leukemia, colorectal, breast, ovarian, hepatocellular carcinoma (HCC), adrenocortical carcinoma (ACC), esophageal carcinoma (EC), nasopharyngeal carcinoma (NPC), squamous cell carcinoma (SCC), follicular lymphoma (FL), prostate cancer and gastric cancer [PMC4496000]. Hsa-miR-150 is another miRNA that has been associated with various cancers and its expression pattern varies depending on the cell context [PMC4496000]. In a study investigating differentially expressed mRNAs targeted by various miRNAs including hsa-mir-483, it was found that hsa-mir-483 targeted 34 significantly differentially expressed mRNAs [PMC6489013]. Other miRNAs such as hsa-miR-3131 and hsa-miR-200a-3p have also been reported in GC profiling studies by Pereira et al. [PMC8900545]. The expression levels of several miRNAs including hsa-mir-483 were found to be similar between ADJ and GC samples in a study corroborating the data obtained by qRT-PCR [PMC6485221].

mRNA interactions 3 total

Genome locations

Gene Ontology annotations


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This sequence is found in 3 other species