SNORA10: SNORA10 is a snoRNA that is absent in nonmammalian species and has a slightly different sequence in Xenopus, targeting 5.8S rRNA instead of 28S rRNA [PMC6984369]. It is highly conserved evolutionarily and is involved in the pseudouridylation of 28S rRNA [PMC6984369]. Mammalian SNORA64 is derived from a recently duplicated ancestral SNORA10, while SNORA34 is derived from SNORA2 [PMC6984369]. Loss of SNORA10 expression does not result in the loss of pseudouridylation modification [PMC6984369]. SNORA10 has been identified as a guide for pseudouridylation at specific positions in 28S rRNA and 18S rRNA [PMC6984369]. It has been found to be expressed in both tumor and adjacent normal breast tissues, along with other snoRNAs from the SNORD116 cluster [PMC5951800]. Dysregulation of snoRNAs, including SNORA10, has been associated with various types of cancer, and their overexpression has been linked to tumorigenesis and patient survival time [PMC3328434][PMC5747948][PMC4175554]. In a study, the methylation status of SNORA10 was found to be significantly unmethylated in tumor cells, making it one of the input variables for developing a multivariable function for cancer prediction [PMC6751714].
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