Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) hsa-miR-4640-3p URS000002EB45_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

hsa-mir-4640: Hsa-mir-4640 is a microRNA (miRNA) that has been found to have a disruptive potential on miRNA function due to a novel "CT" deletion [PMC4159108]. This deletion has been observed in 7 out of 14 globally diverse populations and alters the predicted mRNA targets of hsa-mir-4640 [PMC4159108]. The deletion adds 3 additional targets and removes all of the original 79 predicted targets from regulation [PMC4159108]. MiRNA target prediction was done with and without the "CT" deletion using DIANA prediction software [PMC4159108]. In the absence of the mutation, the 3' strand of hsa-mir-4640 was predicted to target 316 binding sites in 79 genes [PMC4159108]. Furthermore, this "CT" deletion has been found in individuals from various populations, including Pygmy, Sandawe, Yoruba, Maasai, African-Americans, Mexican-American, and Gujarati Indian individuals [PMC4159108]. In addition to hsa-mir-4640, other miRNAs such as hsa-miR-520a-5p, hsa-miR-214-3p, and hsa-miR-525-5p have also been found to be related to overall survival using Kaplan Meier plotter software [PMC7757131]. Moreover, low expression levels of certain miRNAs including hsa-mir-4640 have been associated with a higher survival rate [PMC8321750]. Overall, these findings highlight the importance of understanding the disruptive potential of genetic variations on miRNA function and their impact on overall survival.

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences
CACCCCCUGUUUCCUGGCCCAC

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Publications