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Homo sapiens (human) small nucleolar RNA, C/D box 74 (SNORD74) URS000002951F_9606

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SNORD74: SNORD74 is a C/D box small nucleolar RNA (snoRNA) that has been found to be upregulated in various diseases, including metastatic disease in prostate cancer [PMC8389557]. Mutations in SNORD74, as well as SNORD77 and SNORD80, have been shown to affect the formation of secondary Kink-turn structures [PMC7154078]. SNORD74 is one of the snoRNAs that are encoded within the introns of the GAS5 gene [PMC4159348]. It has been found to be associated with nucleolar reads and is upregulated in prostate cancer [PMC4159348] [PMC6163368] [PMC10001105]. Abundant small RNA-derived RNAs (sdRNAs) have been identified from SNORD74, with three sdRNAs mapping to different regions of the snoRNA [PMC4627319]. The expression levels of SNORD74 have also been found to be associated with overall survival and poor clinicopathological features in lung cancer and ovarian cancer patients [PMC7862201] [PMC9598326]. Additionally, sdRNAs derived from SNORD74 have shown differential expression in various cancers, including prostate cancer and lung adenocarcinoma [PMC9149963]

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