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Rattus norvegicus (Norway rat) microRNA rno-mir-21 precursor URS0000013967_10116

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rno-mir-21: Rno-mir-21 is a microRNA that has been extensively studied in various biological contexts. It has been found to be enriched in fibroblasts and fibroblast-derived extracellular vesicles (EXOs) [PMC6406975]. Detection probes for rno-mir-21, along with other microRNAs, were purchased for experimental analysis [PMC4905434]. In certain experimental conditions, the expression of rno-mir-21 did not significantly change, while other microRNAs such as rno-miR-340-3p, rno-miR-675, and rno-miR-425 showed significant increases [PMC8810107]. In different studies involving various tissues and experimental models, the expression of rno-mir-21 was found to be upregulated [PMC3682887] or downregulated [PMC3682887] in response to different stimuli. Manipulation of rno-mir-21 expression using mimics or inhibitors resulted in corresponding changes in its expression levels [PMC4519855]. Rno-mir-21 has been implicated in the regulation of various target genes and proteins involved in different biological processes such as cardiac hypertrophy and pain development [PMC5979605] [PMC8914318]. It has also been shown to be involved in the modulation of signaling pathways such as PI3K/AKT/mTOR signaling pathway [PMC5908320]. Overall, these studies highlight the importance of rno-mir-21 as a regulatory molecule with diverse functions across different biological systems.

Genome locations

Gene Ontology annotations


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This sequence is found in 41 other species

  1. Ailuropoda melanoleuca (giant panda) microRNA 21 (ENSAMEG00000021813.2)
  2. Balaenoptera musculus microRNA 21 (ENSBMSG00010019818.1)
  3. Bison bison bison (American bison) miRNA (ENSBBBG00000008444.1)
  4. Bos grunniens microRNA 21 (ENSBGRG00000021122.1)
  5. Bos indicus x Bos taurus miRNA (ENSBIXG00000009322.1, ENSBIXG00005024807.1)
  6. Bos mutus microRNA 21 (ENSBMUG00000004870.1)
  7. Bos taurus (cattle) microRNA 21 (ENSBTAG00000029897.2)
  8. Camelus dromedarius (Arabian camel) microRNA 21 (ENSCDRG00005005060.1)
  9. Canis lupus dingo (dingo) microRNA 21 (ENSCAFG00020026507.1)
  10. Canis lupus familiaris (dog) miRNA (ENSCAFG00000020471.2, ENSCAFG00030004641.1, ENSCAFG00040001500.1, ENSCAFG00845025927.1)
  11. Capra hircus microRNA chi-mir-21 precursor
  12. Catagonus wagneri (Chacoan peccary) microRNA 21 (ENSCWAG00000015264.1)
  13. Cervus hanglu yarkandensis microRNA 21 (ENSCHYG00000000415.1)
  14. Cricetulus griseus microRNA cgr-mir-21 precursor
  15. Delphinapterus leucas microRNA 21 (ENSDLEG00000007389.1)
  16. Dipodomys ordii (Ord's kangaroo rat) miRNA (ENSDORG00000022126.2)
  17. Equus asinus asinus (donkey) microRNA 21 (ENSEASG00005002299.1)
  18. Equus asinus (ass) microRNA 21 (ENSEASG00005002299.2)
  19. Equus caballus (horse) microRNA 21 (ENSECAG00000025574.2)
  20. Mesocricetus auratus (Golden Hamster) miRNA (ENSMAUG00000002742.1)
  21. Microtus ochrogaster microRNA 21a (ENSMOCG00000007742.1)
  22. Monodon monoceros (narwhal) microRNA 21 (ENSMMNG00015018634.1)
  23. Moschus moschiferus (Siberian musk deer) microRNA 21 (ENSMMSG00000017439.1)
  24. Nannospalax galili miRNA (ENSNGAG00000001811.1)
  25. Otolemur garnettii (small-eared galago) miRNA (ENSOGAG00000017260.1)
  26. Phocoena sinus microRNA 21 (ENSPSNG00000014625.1)
  27. Physeter catodon (sperm whale) microRNA 21 (ENSPCTG00005021116.1)
  28. Prolemur simus miRNA (ENSPSMG00000013084.1)
  29. Pteropus vampyrus (large flying fox) miRNA (ENSPVAG00000026322.1)
  30. Rhinolophus ferrumequinum microRNA 21 (ENSRFEG00010010196.1)
  31. Sus scrofa microRNA ssc-mir-21 precursor
  32. Tupaia belangeri (northern tree shrew) miRNA (ENSTBEG00000017959.1)
  33. Tursiops truncatus miRNA (ENSTTRG00000023376.1)
  34. Ursus americanus (American black bear) miRNA (ENSUAMG00000016572.1)
  35. Ursus maritimus miRNA (ENSUMAG00000022707.1)
  36. Ursus thibetanus thibetanus (Asiatic black bear) microRNA 21 (ENSUTTG00000022123.1)
  37. Vicugna pacos (alpaca) miRNA (ENSVPAG00000017008.1)
  38. Vulpes vulpes microRNA 21 (ENSVVUG00000018133.1)
  39. Zalophus californianus (california sea lion) miRNA (ENSZCAG00015022219.1)