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Homo sapiens (human) long intergenic non-protein coding RNA 474 (LINC00474) URS0000CCE02B_9606

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LINC00474: LINC00474 is a long intergenic non-coding RNA (lincRNA) located on chromosome 9 at position 118,667,077 [PMC8282839]. In a study involving affected subjects of subfamily 3, two small insertions/deletions (INDELs) were identified in the genomic region containing the DELEC1 gene and LINC00474 [PMC8282839]. These INDELs were specific to the affected subjects and not present in healthy controls [PMC8282839]. One of the INDELs was a three-base pair deletion in an intronic region of DELEC1 gene, predicted to affect a histone modification site in the brain frontal cortex [PMC8282839]. The other INDEL was a two-base pair deletion at LINC00474 [PMC8282839]. In another study, it was observed that LINC00474 inhibited tumor size, while miR-300 mimic relieved it [PMC7106848]. The regulatory relationship between LINC00474, miR-300, and FOXO1 was also noted in the context of osteosarcoma regulation [PMC7106848]. Furthermore, among the top differentially methylated coding genes (DMCGs), several regulatory RNAs were identified including miRNAs (miR196B, miR550A1, miR4708, and miR2267), small nucleolar RNAs (SNORD114-31 and SNORA15), long non-coding RNAs (LINC00499, LINC01036, LINC00989, LINC00474,and LINC00654), and anti-strand RNAs (IL21R-AS1 ISM1-AS1 DLX6-AS2 LATS2-AS1 TBX5-AS1 HOXA10-AS DLX6-AS2) [PMC9656473]. These regulatory RNAs may play a role in the epigenetic regulation of gene expression [PMC9656473].

Genome locations

Gene Ontology annotations

Sequence

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GUGGGAUAUGAAGCAUGAGACGGAAUGAGGUCACCAAGAGAGUGAAUGUAUAUAAAGCAAAGAGGGUGUCCAAGGGCUGAGUUCUGAGAUACUUCAAUAGCAGAAGAUGAUGCUGAGAAGCAGAAGCCAGCUAAAGAGACUGAGAAAGUGCUGGUGGUGAAGCACCAGGAAAAUCAACAGAUCAUGCUCUGUGUUAGUGGAUUCACAAGCAACCUGUACUCCUCAAAGAAAGAUGAUAAGAUGAAGGAGAUCUCUAGAACCAGCAACUGGGGCUCUUCCUUCAGUGAAAAAAGUGGGUGUAUGCAGACUCAUCCAUCCAUGAAUCUAGAUUGCAGGGAUGUGACCUAUGUAAUGAACUUGCUACUUAUUGCUCAUCAUCAUCUUCUUCAAUGACAAAAAAGAAAAUAGUAACAAUGAAUACGUCUCUUGGGCAAAAUAAAUAAUGAGAUUGUUACAGCAACCUGAUUUUUGAAAAGAAAAAAGGAACUUCCUCGAACUAAAGCAGUUAAGACCUCGACAUUUGCUCAUAGAAAAAGUCGCUGAGUCGUUUCUAGUUGUGAAGGUGCAAAAGAUGCAGUUAUCCCUUAUGGAAAAUUCCAAGAACUUGUGCCUAAUUUGAGUCAUGCAAACCUGAGUUCUGCAUGACUGAGCUCUGUCACUCAAUGGUUGGGAAAUUUGUGAUCAUCUCUACGCCUUGCUUUCUGCAUCUGUAAAGUGGAAAUGAUAAUAUCUACCUUGUGUGAUUCCUGGAAGAAUUAAAUACAUUAUAUUCAAAAAAAAAAAAAAA

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Publications