v24

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Homo sapiens (human) myocardin-induced smooth muscle lncRNA, inducer of differentiation (MYOSLID) URS0000BC4586_9606

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MYOSLID: MYOSLID, a long non-coding RNA (lncRNA), has been shown to directly interact with miR-1286 through luciferase reporter assay and RNA pulldown assay [PMC6911319]. The downregulation of MYOSLID has been found to attenuate TGF-β1-induced Smad2 phosphorylation, disrupt F-actin formation, and block TGF-β1-induced MKL1 nuclear translocation [PMC9458932]. This suggests that MYOSLID plays a crucial role in SMAD activation and subsequent transcription of vascular smooth muscle cells (VSMCs) [PMC9458932]. Furthermore, MYOSLID has been shown to promote the expression of contractile markers in VSMCs by inhibiting their proliferation and migration [PMC9458932]. However, the effect of MYOSLID on contractile gene expression in VSMCs is cellular context-dependent and may be restricted to VSMCs [PMC9458932].

Genome locations

Gene Ontology annotations

Sequence

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GAGUUCAAGUGCUUCUUUAUAAAGGACACUUAACUGAUCUAAAUAUUUGUCAAGCUGAAUCGCUACAUCCACUCUCACCUGCCUGAAAUCAAUAUGCUCAAGUCAAACGCAUUUGCCUGCAUCUGAAUGUGGAGAAUGAACUUCUUAAAGCUGAACUGGCAGCUGGAAGGGGAGAGAGAAGAGCUGGACAGGGAGCCAGGACACCGGAGUUCUUUUCCACUGUGGUGGGAUCUGGAAGAAGCUGUUGAAUCUCUGUAGAGUUAGCUUUUAAAUGCUCCUUGAAUUCUCAGGCAGUGAAUGCACUACCGUGUGCAGAAGGCAAGGACAUGGCUGAGCAUGUUGUUUUCUUCACCUUAUAUGGAGCUUCCUUAACAGGUUCCUGGUGCUGGUUCCAGCAGAAUAGACACAGAGAUGCAUGGCCUAACUCCCACUCCCUCUUCAGGACUGAGCCACGCAGCCCCCCAUCUGCCAGAAGUGUUAGCUGUUGACGGCUCACAGCUGAGUCCCUCUCCAGGCAUUGCUGAAAAGAGCCACCUUGCUCUAGGAUGUGCCCCCACCCUGGGGGCAGCAUACAUUCCAAGUGAUUAGUCCAUAGUGUGGUACAAAGGUUGUACCCAUCUUGCCUGAAUUCAGGAUCUCUUGGAAAACCACCCCAGCUCUGCAGCUCCUGGUGGGGUGCUGAGGCCUCUGCUGCAGCUGCAUCGCAGUUUACUUUCCCCUCUGCCUAGUCCUGCUGCCUUCACUCCCCAACAGGUAUUGUUCCCCAGAGAACUCCCUGCCCCCAGUCACCUGUAAGCAAAUCUCCACUGCAGUCUGUGGCCUGGGAAACCUGCUCUAGGAUCCCAAAGUGAACACAGCUUCCCAUUGAAAUGUGUCUUUGGGUGUUAAUCUGUCCUGCCAUCUUUACAUCUAAUCAAGAGGUAGAGCUUCCCCUGGUGUUCCUGCUGGGUACAUAAAGGAUCUUUUCCAUUGUCAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications