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Homo sapiens (human) lncRNA associated with SART3 regulation of splicing (LASTR) URS0000A77231_9606

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LASTR: LASTR is a long non-coding RNA (lncRNA) that has been found to play a role in cancer development, specifically in lung cancer [PMC8899365]. Depletion of LASTR using GapmeR induces splicing defects in multiple genes essential for cancer cells, leading to a specific impact on cancer cell fitness [PMC7049684]. The lncRNA LASTR has been found to interact with SART3, as validated through RNA affinity purification (RAP) [PMC7049684]. Additionally, LASTR has been shown to be mainly localized in the cytoplasm of cells, suggesting its involvement through a competitive endogenous RNA (ceRNA) mechanism [PMC8899365]. The study also found that c-JUN consistently binds to the LASTR promoter in different cancer cell lines [PMC7049684]. Clinical correlation analysis revealed that higher expression levels of LASTR were associated with worse clinical features in lung cancer patients, including clinical stage and classification [PMC8899365]. These findings suggest that LASTR may have oncogenic properties and could be a potential target for combinatorial therapeutic approaches in cancer therapy [PMC7049684].

Genome locations

Gene Ontology annotations

Sequence

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GUCCAUCCAUCACUUGCAGAAAACAAAAGAGAGCAAGAGAGAAGACAGUGGGUGAAGUCCUGGUUCCAGACUCCCCUUUUUGCCGGGAUAUGAUGGAUCUGUCAGCUGGUGCCUAGAGUCCUAGAGAGCUAGAGAUGGAGGGAAAUUCAGAUCAUCUAAACCCUUCAGCCCUUCACUGGACAGAAGAGGAAACUGAGGCUCCAUCUGCAUGACGUUCCCAGAGUCACGGCACAAAUUCAUGGAAGAAGCAGCAGGAAACUCAGUUCUCCAGUCUGGGUCCAAUGUGUGUUUUAGAAAUAUCUCCACAGGGUUAAUGACUCAAUUUUUCAUGCAUGAUUGCUAGUAAUGACAAUCAUGUUAUGUUUGUUUCUGUAGCUUUGGAAAUCACUCCUUCCACUUGAGUUUCAGGUCCCAACUGUCCACACCUGCAGGAGUGAGGUUUUGCUGAGACUGAUAAGGCACUCACAUUUUGUGGGAGUUGAAUUGUCUCUGUAGCCUAGAAUCUAGAUUUUUUUCCCUCCUCUGCUCUCAGUGAACGGAGAAUUCCAUCUCGGUACAAUCUGUGAACCAUUCUGCAGUAAGAUUGUCAUCGUCUCAUUCAUACUACCUGGUCGGUAACACAAAGGGCUGUAAUUGAUGUGGUUCAGAGACUCACAUCCAAGCAAUAAAAAUGAAUCCCUUAUGGUGGUCUGCAGCAACGCAAAAAAAAAAAA

Taxonomic tree

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Publications