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Homo sapiens (human) IGFL2 antisense RNA 1 (IGFL2-AS1) URS0000A76D1B_9606

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IGFL2-AS1: IGFL2-AS1 is a long non-coding RNA (lncRNA) that has been found to be m6A modified and this modification can be reversed with chronic pazopanib treatment [PMC10086028]. It has been identified as a differentially transcribed gene that is highly expressed in radioresistant colorectal cancer (CRC) compared to radiosensitive CRC [PMC9866146]. IGFL2-AS1 has been predicted to interact with the 5'-UTR region of AR mRNA [PMC10086028]. High expression of IGFL2-AS1 has been associated with poor prognosis in patients with colorectal adenocarcinoma (COAD), suggesting its potential as a novel tumor marker [PMC8349208]. In endometrial tissues, the expression of IGFL2-AS1 was found to be significantly different between EMS tissues and control endometrial tissues [PMC8980742]. Additionally, IGFL2-AS1, along with nine other lncRNAs, was identified as a diagnostic and prognostic biomarker for clear cell renal cell carcinoma (ccRCC) due to its strong correlation with clinicopathological characteristics [PMC6874440]. In ccRCC cell lines and tumors, IGFL2-AS1 was found to be upregulated along with three other lncRNAs, while five other lncRNAs were downregulated [PMC6874440]. Furthermore, IGFL2-AS1 has been reported to be packaged into extracellular vesicles (EVs), allowing it to transmit sunitinib resistance information between renal cell carcinoma cells [PMC9893571].

Genome locations

Gene Ontology annotations

Sequence

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AGCCCAGUUGCACCCAAGUAAAAUAAACAGUCUUGUUGCUCACACAAAGCCUGUUGGUGGACUCUCUUCAUAUGGACUCAUGUGACAUUUGGUGCCGAAGACCUGAGACAGGAGGACUCCUUUGGGAGACCGGUCCCCUGUCCUCGCCCUCUCUCCAUGAGAUCCACCCAUGACCUCGGGUCCUCAGCCCAGCCGAAGGAACUUCUCACCAAUUUUAAAUCGGGGACGCAAAGCCAACAAGAAUGAAGAAGUGGCCAGGAAAUUAAAGCAAUGUGAACACCCUCUGGCCAGCCUGUUGGAGGGUGAGAGACCACAUGGAGGAGACAGAGCCCUGAUGUCCCAGCUGAGGACAUCCCAGAAAAGCCUAUUUCCAGACAACUGAGGACAGGUGAAUGAGUUCUUUGUAGAUGAACCAGAAUCCAGUCUAUCUACCUGCUGAGCACAGACAUGUGAGCAACCCCCCCAUCAAGGUCAACUGAGCCUGGCCCAGAUCAACAGAAUCACGAGAUGACCUAUGGACUCAGGAGCAAUCAUGAUGUGGUUGUUCCAUGACACUGAAUGUAGAGGUCGUUGAUUCUGCAGCACCAGCAAACUGACACAUAACACCGUGUUUAAUAUUGGGUUCUGGGCUUUGGGGUCCCUGCAGAGUUCCUGAUUUCAGCCCCAAGGGCUCAUUCACAAAUUUAUUACUCAGAUUCUACCCUGUCAACCCAGGACGUGUUACUUACACAUUUCCCAGUGUGGGCAGCAAGCCACCCAGGUGCCGAGGCAAGAGACCGAGGGCACAAGCUGUUCCAGUAUAAUAAAGAAAACAUAUAAAAUAAGAAUAGUUAUACUAGAUAUAGAUCGUAGAUAUGAUUAUAUAUGAAUAUUACUAAUCAUUAGUCUGUAGCAAUUACUCUUUAUUCCAUUAUAAUAAUAAUCUUCUCUCUACAAUUAUAACUUAAGAGAAACCAGGCCAUACAGAGAUAGGAGCUGAACGGACACAGUGAGAAAUGACCAGAAGACAAGAGUGUGAGCCUUCUAUUAUGCCCCGACAGGGCCACUAGAGGGCUCCUUAGUCUAGCGUUAAUGCCAGUGCCCGGGAAGAUGCCCGUUACCUAGCCGACUUUGGUCUAGCGGUAGCGUCAGUGCCCAGGAAAAGCACCCACUACUUAGCAGACUGGGAAAAGGAGUGUCCCUUUCCCCGGGGGAGUUAGAGAAGACUCUGCUCCACCACCUCUUGUGGAGGGCCUGACAUCCGUCAGGCCUGCCCGCAGUUAUCCAGAGGCCUGUCUCCCUGUGAUGCUGUGCUUCAGAGCAGUCACGCUCCUGGUCCGCUUACAUGUUCCAUCCUGUACACCUGGCUCUGCCUUCUAGGUAGUAGCAGAAUUAGUGAAAGUACUAAAAGUCUCUGAAAUGCAAAAAUAAAGGCAUAAGCUGUCUCCUUUCUCUCCACCUCAGCUGCCAAACAGGGAAGGGCCGCCUGUCCAGUGGAUACAUGACCCACAUGACCUUACCUAUCAUUGGAGAUGGCUCACACUGCUCACCCUGCCCCCUUGUCUUGUAUCCAAUAAAUAACAGCGCAGCCUGGCAUUCGGGGCCACUACUGGUCACUGUGUCUUGGUGGUAGUGGUUCCCCGGGCCCAGCUGUUUUUUCUUUUAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications