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Homo sapiens (human) competing endogenous lncRNA 2 for microRNA let-7b (CERNA2) URS0000A76542_9606

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CERNA2: CERNA2, also known as competing endogenous lncRNA 2 for microRNA let-7b, is a long non-coding RNA (lncRNA) that has been identified as an oncogenic RNA in ovarian cancer [PMC8541687]. It has been found to be abundantly expressed in ovarian cancer compared to normal ovarian tissues [PMC8541687]. In addition to ovarian cancer, CERNA2 has also been implicated in other types of cancer, including cervical cancer and gastric cancer [PMC9563963]. It has been shown that CERNA2 silencing suppresses the migration of cervical cancer cells and downregulation of CERNA2 suppresses proliferation and triggers apoptosis of gastric cancer cells [PMC9563963]. Furthermore, CERNA2 is involved in the regulation of the IFN-γ signaling pathway and inflammatory levels [PMC8278092]. It is positively correlated with STAT1, indicating its role in fine-tuning the regulation of IFN-γ signaling pathway [PMC8278092]. Additionally, CERNA2 is upregulated in psoriatic skin compared to normal skin but not significantly due to heterogeneity of clinical samples [PMC8278092]. Overall, CERNA2 plays a role in various types of cancers and its dysregulation can impact cell functions and signaling pathways involved in oncogenesis.

Genome locations

Gene Ontology annotations

Sequence

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CAGUAGCUUGCCGAUGCUCCCAGCUGAAUAAAGCCCUGCCUUCUACAACUCAGUGUCUGAGAGGUUUUGUCUGCGGCUCACCCUGCUACAUUUCUUGGUUCCCUGACUGGGAAACGAGGUGACUGACGGAUGGCCGAGGCAGCCCCUUAGGCGGCUUAGGCCUGCCCUGUGGAGCAUCCGUGAGGGGAACUCCGGCCAGCCUGAGUGACGUGAUCCAAAGAGCGCUCCCGGGUAGGCAAUUGCCCCAAUGGAACGCCUUGCCAGAGCAGCGUGUAGCAGGCCCCCACGGAAGAUUAACACAGUGGCUGAACACCAGGAAGGAACUGGCACUUGGAGUCCGGACAUCUACAACUUGGCCCAACCACCGAGACCACCCUUAAACAUCAGUAGACUGGGAGCUGUACGUGGAUGGGAGCAGCUUUGCCAACCCUUGCAAAGUGACUCUGAAGAAGACGACAAGCCUUGUUCCGGUCACACCCGGAAGCUGACUGGUUCACGCAUGGCCGAAGCAUGAGGAAACUCAUCGCGGGAAUAAUUUUCCUUAAAAUUUGGACUUGUACAGUAAGGACUUCAACUGACCUUAUGCUAAGCUGCCUGAUCAGUGGACAGGUAGCUGUGUAAUUGGACAGGUAGCUGUGUAAUUGGCACCAUUAAGCCAUCUUUCUUCUUACUGCCAAUAAAAACAGGUGAACUUCUAGGCUUCCUAGUCUAUGCUUCCCGUGAAAAAUGAAGCAUAGCCAUAGGUGAUUAGAAAAUAAUGAAUGGCCCCCUGAAAGAAUCAUACAAUACUAUAGACCCACCACUUAGGCACAAGAUGGCUCAUGAGGAUAUCGAACCCCCAUCUACAUGCUCAACCGAAUCAUACAGUUACAAGCGGUUUUAGAAAUUAUUACUAAUAAAACCGGUCAAGCCUUGACUGUUCUUGCCCGGCAAGAGACUCUGAUGAGAAAUUUUAUCUAUCAAAAUAUACUAGCUCUUGACUACUUGCUAGCAGCUGAAGGAGAAGUUUGUAAAAAAUUUAACCUUACUAAUUGUUGUCUACACAUAAAUGAUUAAGGGCAAGUAGUUAAAAAUAUAGUUAAAGAUAUAACAAAACUGGCACAUGUACCCAUGCAAGUGUGGCAUGGGCUCAAUCCGGGAGCCAUGUUUGCAAAUUGGUUCCCAGCAAUGAAAAAAUUUAAAACUCUUAUAAUAAGAGUAAUAAUAGUAAUAGAAACCUGCUUACUGCUCCUUUGUCUGAUACCUGUAUUUCUCCAAAUGAUAAAAAACUUUGUCACGACCUUAGUUCACCAAAAUGCUUUAGCAGAAGCAUACUAUAUAAAUCACUAUCAAUCUAUUGCACAAAAAGACAUAAGUAGCAAAAAUAAGACUCAGAACUCCCACUAAUAAAAACUGAGAGUCUCAAAGGGGGGAAAUGAGGGAAGAGAGAGAGACCCUCUCAUAUUGUUUUAUAUUGUUUUAUACUCAGUACCUCUUUUAAGAAAAAGUGACAAGGAAGUAAAACCAAAGACAGGCAGCCUGGUGCCAGGCCUGAAACCAGGCCUGGGCCUGUCUGGCCUAAACCCAGUAGUUAAAAAUCAACUCAUAACUUAGAAACUGAUGUUAUUCAUAGAUUCCAGACAUUGUAUAGAAGAACAUUGUGAAACUCCCUGCCCUGUUCUGUUUCUCUCUGACCACUGGUGCAUGCAGCCCCUGUCAUGUACCGCCUGCUUGCUCAAAUCAAUCACGACCCUUUCAUGUGAAAUCUUUAGUGUUGUGAGCCCUUAAAAGGGACAGAAAUUGAGUAUUUGGGGAGCUUGGAUUUUAAGGCAGUAGCUUGCUGAUGCUCCCAGCUGAAUAAAGCCCUUCCUUCCACAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications