v24

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Homo sapiens (human) PRKAR1B antisense RNA 2 (PRKAR1B-AS2) URS00008E3A42_9606

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PRKAR1B-AS2: PRKAR1B-AS2, a long non-coding RNA (lncRNA), has been found to be positively correlated with PI3K-110α expression at both the mRNA and protein levels (Li et al., 2021 [PMC7918312]). Knockdown of PRKAR1B-AS2 leads to the downregulation of mTOR and PI3K/AKT signaling pathways (Li et al., 2021 [PMC7918312]). Additionally, PRKAR1B-AS2 knockdown induces apoptosis, as demonstrated by annexin V/PI flow cytometry analysis (Li et al., 2021 [PMC7918312]). In vivo experiments show that silencing of PRKAR1B-AS2 attenuates tumor growth and improves the response to cisplatin treatment (Li et al., 2021 [PMC7918312]).

Genome locations

Gene Ontology annotations

Sequence

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UGCAGCCAGGCACUGUCCGUCCCGGGACCUACGCAGCUGCCAUGGAAGCUCCGGGUUUCGCAGGAGACUGGAAUAAGAUCGGAAUAAUUCCAACAGAUGCUCCAACCAUCCCUCAUGGACCACACGCACUCUUGGAUGCUGAAGAGCAGGCUGGGGUCUGGGGCAGCCUUUAGGGGCUCUUGGGACCCCAAAGGUGUCCAGCUUGGAUGUCUCCAGCAGAUCUUUCUGGAAAUCUGGGACACCAAGGAGGAGCACAAAUGCUGGUCUUACUACUAAGCAAUAUGUCCCUCGGAUCCAAAGGAGAGCAGGUGACCUGGGUGCAGCCACAGCCAGCUGCCACCUCCCUGGAGUCCCUCAUGAAGCAAUGCAUUCAGGGCAGAAUCCAUUGCUGCCUCAGCCCCCUUCAAAGACCAGGCCCAACACCGCACCAGCUCCUUGGACACUGCCCAUCUUCCCAGGGAGAGUCUCGUGCUCAGAGAGGCUAUAAAUAUACGCCGGACAGUCAAGAGUUUCCGUCGCCAACAGAAGAGCUGAGCAAAAGGUGAAAUAAACAUCCCGUGGCUGCAAAUUAAAAAAAAAAAAAA

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Publications