SNHG19: SNHG19 is a long non-coding RNA (lncRNA) that is downregulated in certain conditions, such as in the human AD brain [PMC9892334]. In the context of Alzheimer's disease (AD), SNHG19, along with other lncRNAs such as LINC00672, RNF144A-AS1, LY86-AS1, and LINC00639, has been found to be associated with the pathology of AD [PMC7594522]. FISH analysis has shown that SNHG19 RNA co-accumulates with polyadenylated RNA in pA+ RNA foci [PMC5972229]. In cells depleted of ZFC3H1, a protein involved in RNA degradation and processing, SNHG19 RNA is stabilized but does not accumulate in nuclear foci [PMC5972229]. SNHG19 has also been found to be upregulated during viral infection [PMC7111612]. In mice, SNHG19 has been shown to correlate with several protein-coding genes involved in various biological processes such as leukocyte transendothelial migration and apoptosis [PMC7809420]. Depletion of MTR4 or ZFC3H1 and ZCCHC8 does not result in pA+ or SNHG19 RNA accumulation in nuclear foci but instead leads to a more diffuse distribution of these RNAs within the nucleoplasm [PMC5972229]. References: - [PMC9892334]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9892334/ - [PMC7594522]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594522/ - [PMC5972229]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972229/ - [PMC7111612]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111612/ - [PMC7809420]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809420/