v24

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Homo sapiens (human) LRP1 antisense RNA (LRP1-AS) URS00008E396F_9606

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LRP1-AS: LRP1-AS, a natural antisense transcript of the LRP1 gene, has been identified as an antisense RNA that regulates the Low-density lipoprotein receptor related protein 1 (LRP1) [PMC9441681]. It has been found that LRP1-AS disrupts LRP1-mediated Aβ clearance by directly binding to high-mobility group box 2 (Hmgb2) [PMC7140545]. This binding inhibits the Srebp1a-dependent transcription of LRP1, thereby affecting its function in Aβ clearance [PMC7140545].

Genome locations

Gene Ontology annotations

Sequence

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GUGCACCCCUGCUGCAUGAGGCUCAGCCCCAGGGGUCCAACAGAGGUCACAGUCACAGCACAGAAUGGAAGGCUUGCAGGGAGGGCUGCCCUGGAGGGCAGAGUGAAAGCAGGGGAAAGCUGCAGCCUUUCUUCUUCGUCCUCCUUGGGGAGCUAAUUACAGGCCAGCAGCCACUGUGCAGGAGCGGUUAUCCGGCUGCAGGAGGUAUCCUUCAACACAGCCACAUAUGAAGGAGCCGUCUGUGUUGGUGCAUAGCUGGCUGCAGGUGCCGUACACUGAGCACUCAUCAAAAUCUGCCGAGGAAAGGGCAAGAAUGUGGUCAUUUCCAGUGUGACAAGGGCAACGAAGUGGGUGAUCAUCAGACAUGAUCAACAUGUCCAUCCUUACAGCUACCUUGAAGGACAGUUCGGCAGAAUCUAUUACAGCAUGAAAUGUGCAAACCUUAACACCCAGCAAGUCCAGUCUUGGAAUCCACUCUAGAGAAACACUCGUGUACAUAUCACUCAUCCACGCAGGGAAGAUUUAUUGAGUCCCUACUAUGGGUCAGGUGCCAGGGGUGCAUCAGUGAACUUUAAAAUAGACCCACAUUGCUGUCCUCAUGAAACUUAUAUUCAGAUAAUAAAUGAAAUAUAGUUACUAUAAUAAAAAAAAAAAA

Taxonomic tree

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Publications