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Homo sapiens (human) TGFB2 overlapping transcript 1 (TGFB2-OT1) URS00007E4360_9606

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TGFB2-OT1: TGFB2-OT1 is a long non-coding RNA (lncRNA) that acts as a competing element to inhibit the binding of GSK3β to β-catenin [PMC10024539]. Overexpression of TGFB2-OT1 leads to increased expression of ATG3, ATG7, and p62, possibly through upregulating LARP1 by sponging miR-4459 [PMC10024539]. TGFB2-OT1 also prevents miR-3960-mediated repression of CERS1, resulting in increased production of C18-ceramide and induction of mitophagy through interaction with LC3-II-containing autophagolysosomes upon Drp1-dependent mitochondrial fission [PMC10024539]. Ectopic expression of TGFB2-OT1 induced by VEC inflammation activates autophagy by increasing the expression of ATG13, ATG3, ATG7, and p62 [PMC10024539]. Inhibiting TGFB2-OT1 with a small molecular inhibitor 3BDO reduces autophagic and inflammatory reactions [PMC10024539]. Intervening in TGFB2-OT1 could be a potential treatment strategy for infectious and autoimmune diseases due to the intricate correlation between autophagy and inflammation [PMC5680586][PMC10024539][PMC5680586]. In contrast to its deletion in tumors, the lncRNA GAS5 is upregulated in osteoarthritis (OA) where it represses autophagy and stimulates apoptosis in OA chondrocytes. This repression is responsible for cartilage degradation and OA pathogenesis. GAS5 represses autophagy possibly through downregulating Beclin 1, ATG3, ATG5, ATG7, ATG12, and LC3B expression. While GAS5-repressed autophagy enhances drug sensitivity, it contributes to the occurrence of OA [PMC5680586]. TGFB2-OT1 expression is significantly associated with various clinicopathological features of hepatocellular carcinoma (HCC) patients, including age, cirrhosis, tumor size, tumor encapsulation, tumor protrusion from the liver surface, and alpha fetoprotein (AFP) levels [PMC10024539].

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Sequence

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UUCUUUCAUUAUUAUGACAUAAGCUACCUGGGUCCACUUGUCUUUUCUUUUUUUUGUUUCACAGAAAAGAUGGGUUCGAGUUCAGUGGUCUUCAUCUUCCAAGCAUCAUUACUAACCAAGUCAGACGUUAACAAAUUUUUAUGUUAGGAAAAGGAGGAAUGUUAUAGAUACAUAGAAAAUUGAAGUAAAAUGUUUUCAUUUUAGCAAGGAUUUAGGGUUCUAACUAAAACUCAGAAUCUUUAUUGAGUUAAGAAAAGUUUCUCUACCUUGGUUUAAUCAAUAUUUUUGUAAAAUCCUAUUGUUAUUACAAAGAGGACACUUCAUAGGAAACAUCUUUUUCUUUAGUCAGGUUUUUAAUAUUCAGGGGGAAAUUGAAAGAUAUAUAUUUUAGUCGAUUUUUCAAAAGGGGAAAAAAGUCCAGGUCAGCAUAAGUCAUUUUGUGUAUUUCACUGAAGUUAUAAGGUUUUUAUAAAUGUUCUUUGAAGGGGAAAAGGCACAAGCCAAUUUUUCCUAUGAUCAAAAAAUUCUUUCUUUCCUCUGAGUGAGAGUUAUCUAUAUCUGAGGCUAAAGUUUACCUUGCUUUAAUAAAUAAUUUGCCACAUCAUUGCAGAAGAGGUAUCCUCAUGCUGGGGUUAAUAGAAUAUGUCAGUUUAUCACUUGUCGCUUAUUUAGCUUUAAAAUAAAAAUUAAUAGGCAAAGCAAUGGAAUAUUUGCAGUUUCACCUAAAGAGCAGCAUAAGGAGGCGGGAAUCCAAAGUGAAGUUGUUUGAUAUGGUCUACUUCUUUUUUGGAAUUUCCUGACCAUUAAUUAAAGAAUUGGAUUUGCAAGUUUGAAAACUGGAAAAGCAAGAGAUGGGAUGCCAUAAUAGUAAACAGCCCUUGUGUUGGAUGUAACCCAAUCCCAGAUUUGAGUGUGUGUUGAUUAUUUUUUUGUCUUCCACUUUUCUAUUAUGUGUAAAUCACUUUUAUUUCUGCAGACAUUUUCCUCUCAGAUAGGAUGACAUUUUGUUUUGUAUUAUUUUGUCUUUCCUCAUGAAUGCACUGAUAAUAUUUUAAAUGCUCUAUUUUAAGAUCUCUUGAAUCUGUUUUUUUUUUUUUUAAUUUGGGGGUUCUGUAAGGUCUUUAUUUCCCAUAAGUAAAUAUUGCCAUGGGAGGGGGGUGGAGGUGGCAAGGAAGGGGUGAAGUGCUAGUAUGCAAGUGGGCAGCAAUUAUUUUUGUGUUAAUCAGCAGUACAAUUUGAUCGUUGGCAUGGUUAAAAAAUGGAAUAUAAGAUUAGCUGUUUUGUAUUUUGAUGACCAAUUACGCUGUAUUUUAACACGAUGUAUGUCUGUUUUUGUGGUGCUCUAGUGGUAAAUAAAUUAUUUCGAUGAU

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