v27

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Homo sapiens (human) TGFB2 overlapping transcript 1 (TGFB2-OT1) URS00007E4360_9606

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tgfb2-ot1: TGFB2-OT1, a long non-coding RNA (lncRNA), has been identified as a regulatory element in cellular processes, particularly in autophagy and inflammation [PMC10024539]. It functions by competitively inhibiting the interaction between GSK3β and β-catenin, which is a crucial pathway in cellular signaling [PMC10024539]. TGFB2-OT1 overexpression is associated with increased levels of autophagy-related proteins such as ATG3, ATG7, and p62 by sponging miR-4459 and upregulating LARP1 [PMC10024539]. Additionally, TGFB2-OT1 can enhance the production of C18-ceramide by preventing miR-3960 from repressing CERS1, which promotes mitophagy through the interaction with LC3-II-containing autophagolysosomes [PMC10024539]. The ectopic expression of TGFB2-OT1 induced by vascular endothelial cell (VEC) inflammation can activate autophagy pathways and is modulated by small molecular inhibitors like 3BDO that reduce TGFB2-OT1 levels and subsequent inflammatory responses [PMC10024539]. The potential therapeutic implications of targeting TGFB2-OT1 are underscored by its association with various clinicopathological features in hepatocellular carcinoma (HCC) patients such as age, cirrhosis, tumor size, tumor encapsulation, tumor protrusion from the liver surface, and alpha fetoprotein levels [PMC10024539].

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Sequence

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UUCUUUCAUUAUUAUGACAUAAGCUACCUGGGUCCACUUGUCUUUUCUUUUUUUUGUUUCACAGAAAAGAUGGGUUCGAGUUCAGUGGUCUUCAUCUUCCAAGCAUCAUUACUAACCAAGUCAGACGUUAACAAAUUUUUAUGUUAGGAAAAGGAGGAAUGUUAUAGAUACAUAGAAAAUUGAAGUAAAAUGUUUUCAUUUUAGCAAGGAUUUAGGGUUCUAACUAAAACUCAGAAUCUUUAUUGAGUUAAGAAAAGUUUCUCUACCUUGGUUUAAUCAAUAUUUUUGUAAAAUCCUAUUGUUAUUACAAAGAGGACACUUCAUAGGAAACAUCUUUUUCUUUAGUCAGGUUUUUAAUAUUCAGGGGGAAAUUGAAAGAUAUAUAUUUUAGUCGAUUUUUCAAAAGGGGAAAAAAGUCCAGGUCAGCAUAAGUCAUUUUGUGUAUUUCACUGAAGUUAUAAGGUUUUUAUAAAUGUUCUUUGAAGGGGAAAAGGCACAAGCCAAUUUUUCCUAUGAUCAAAAAAUUCUUUCUUUCCUCUGAGUGAGAGUUAUCUAUAUCUGAGGCUAAAGUUUACCUUGCUUUAAUAAAUAAUUUGCCACAUCAUUGCAGAAGAGGUAUCCUCAUGCUGGGGUUAAUAGAAUAUGUCAGUUUAUCACUUGUCGCUUAUUUAGCUUUAAAAUAAAAAUUAAUAGGCAAAGCAAUGGAAUAUUUGCAGUUUCACCUAAAGAGCAGCAUAAGGAGGCGGGAAUCCAAAGUGAAGUUGUUUGAUAUGGUCUACUUCUUUUUUGGAAUUUCCUGACCAUUAAUUAAAGAAUUGGAUUUGCAAGUUUGAAAACUGGAAAAGCAAGAGAUGGGAUGCCAUAAUAGUAAACAGCCCUUGUGUUGGAUGUAACCCAAUCCCAGAUUUGAGUGUGUGUUGAUUAUUUUUUUGUCUUCCACUUUUCUAUUAUGUGUAAAUCACUUUUAUUUCUGCAGACAUUUUCCUCUCAGAUAGGAUGACAUUUUGUUUUGUAUUAUUUUGUCUUUCCUCAUGAAUGCACUGAUAAUAUUUUAAAUGCUCUAUUUUAAGAUCUCUUGAAUCUGUUUUUUUUUUUUUUAAUUUGGGGGUUCUGUAAGGUCUUUAUUUCCCAUAAGUAAAUAUUGCCAUGGGAGGGGGGUGGAGGUGGCAAGGAAGGGGUGAAGUGCUAGUAUGCAAGUGGGCAGCAAUUAUUUUUGUGUUAAUCAGCAGUACAAUUUGAUCGUUGGCAUGGUUAAAAAAUGGAAUAUAAGAUUAGCUGUUUUGUAUUUUGAUGACCAAUUACGCUGUAUUUUAACACGAUGUAUGUCUGUUUUUGUGGUGCUCUAGUGGUAAAUAAAUUAUUUCGAUGAU

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