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Homo sapiens (human) CEBPB antisense RNA 1 (CEBPB-AS1) URS00007E368D_9606

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CEBPB-AS1: CEBPB-AS1 is an antisense RNA that negatively regulates the transcription of CEBPB, a transcription factor involved in the sensitivity of cutaneous malignant melanoma (CMM) tumors to BRAFi-based therapy [PMC7469874]. Knockdown of CEBPB-AS1 using siRNA resulted in a decrease in colony formation and proliferation of CMM cells, as well as sensitization to BRAFi-induced cell death [PMC7469874]. CEBPB-AS1 was found to bind to the zinc finger protein CTCF and recruit it to the promoter region of CEBPB, leading to a decrease in CEBPB expression [PMC7469874]. Knockdown of CEBPB-AS1 also resulted in increased DNA methylation and trimethylation of histone H3 at lysine 27 at the regulatory region of CEBPB, indicating a silencing effect on chromatin [PMC7469874]. The knockdown of CEBPB-AS1 increased the binding of CEBPB to its own promoter region [PMC7469874]. Manipulating the expression of CEBPB-AS1 may represent a potential strategy for resensitizing BRAFi-resistant melanoma cells to therapy [PMC7469874]. The involvement and regulation of lncRNAs like CEBPB-AS1 in gene expression and epigenetic modifications have been previously reported [PMC7469874]. Knockdown of CEBPB-AS1 also potentiated the proapoptotic effect of vemurafenib, a BRAFi, on melanoma cells [PMC7469874]. The expression levels between CEBP-B and its antisense transcript were found to be correlated using Spearman's rank correlation analysis [PMC7469874]. Additionally, other lncRNAs have been identified as highly expressed in monocytes, including GAS5, LINCPINT, ITGB2-AS1, and FGD5-AS1 [PMC5890390].

Genome locations

Gene Ontology annotations

Sequence

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AGCAGUGGCCGGAGGAGGCGAGCAGGGGCUCGGGCAGCUGCUUGAACAAGUUCCGCAGGGUGCUGAGCUCGCGCGACAGCUGCUCCACCUUCUUCUGCAGCCGCUCGUUCUCGGCCGUGAGCUCCAGGACCUUGUGCUGCGUCUCCAGGUUGCGCAUCUUGGCCUUGUCGCGGCUCUUGCGCACGGCGAUGUUGUUGCGCUCGCGCCGGAUCUUGUACUCGUCGCUGUGCUUGUCCACGGUCUUCUUGGCCUUGCUCUUGACCUGCGAGGGCGCCGGCGCGGCCCCCGCGUAGCAGGCGGUCGGGGGCGCCUUGGCGUCAGCGGGGCUCGGCGUGCCGGGCGGGCUGGACGAGGAGGACGUGGAGAGGCUCCCGCUGCUGCCGCUCGGCACCGCCUGGUAGCCGAGUUCUUGCCCCCGUAGUCGUCGGAGAAGAGGUCGGAGAGGAAGUCGUGGUGCUGCCCGGAGGAGGCGGGCGCGGGGGCGGGCGCGGGCGGAGCCGCCUCGAAGGUGUCCGUGGCCGUGGCGGGCGCCGGGGCCUGCGGCGCGCCCAGCGGCUCCAGGUCCCCGGCUUUAGAAAGAAGACUUGACGCCUGUGACGACUCCCCUCUUAAGCCACAGACAAUAUGAGGACCCCGGGGGUCGGCGCGACCGGGCAGGAUCGCGCCCCGCUUGGGGCUGGACCCUGGUCCACGGAGCCCCGCCCCUAGCCCCGCCCACCACACCUGCCGCCUGCUCGAGGCUUGGACACGCCCGGGUCUUCUCUUGCCCCGCGCUGCGCCACCCGACCUGGGCCCUGGGAUGGGGCAGGGGCGGGGGGUGCUCGGCCCUGCCACACUGUGUGACCUUGGGAAGAUGCUUUUGCUGCUGCCAUUUCACAGACGGGAAAGCGACAACGGCCCGCCUGGACUUGAACACAGGCCCAAGGCCUUCUGACCACUUGCCCGCCUCUGCUGGUCUUGCUGUCUGUCCCCACGGCCUUCACUACUGUGUCCCUGGUGCCUAGAACAGAGCCUGGUACAUAGAAGGUGCUCGAUGAAUGCUUUUCCCUAUCCCAUUUUCAAGAGGAGAAAACUGAGGCGAUUUGCCAAGGGGAGAUCCACGUGGCUGCUUUGACAGAGAGUGUUCUGCAAAAGGGCUUAGAAAUCAGCCAGCAGGUGGCAGGUUCUGGGACUGCAGGAGCCAUUCACAUGCGUGAAGAUCCGCUGGGCGCCCUUGCUCUGGGAUCAGGAAAGGCCGGUGCCAUGGAUGUGAUAGAUGCACACAGGGCAUCAGCAGGCCGCCGAGAGGAACCAGAGUGUCCAACGAACAGAAAACAGUGCUCAACCUUCACAUUUAUCGAAUGUUCCUUGGCACAUGCUGUAAUUCUGGCCCUAAAGACACAUUCAUGGACAAGACAAGCAAUUCCUGUUCUCGUGGAGCUGAAAUUCUCCUGGGGGAAGACAAGCACUAAACAAGAUCAAUGAUUAAAGUAUAGAUUGUAUUAGAUUCUGGUCAGCACUAUGGAGGAAAAUACAGCAGGGGAGCAGAGCAGGAGUUCUGGGAGAUUUGAUUUUUUGUUUUCUGGGGUUUUUUGUUUGUUUGUUUUUUGAGACAGGGUCUCACUGCUGGAGUGCAGUGGCACGAUCUCUGCUCACUGCAGCCUCUGCUUCUUGGGCUCAGGUGAUCCUCCCACCUCAACCUCCCAAGUAGCUGGGACCACAGGGGCAUGCCACCACACCCAGCUGAUUUUUUAAUGUUUUGUAGAGAUCAGGUCUCAUUAUAUUGCCCAAGCUGGGGGAGUUGAUUUUAACUUUAUGUUAGAGUAGUCAGGGAAGACCUCACUGAGGUGACAUUUAAGCAAAAACCUGAAUGUGGUGAAGCAGGUAUCUGGGGGACCUUGGACCACACAAAGGGAACAGCAAGUGCAAAGGCCCUGAGGUAGGAGCACGUAGUUGUGGUGAUGACGGAGAGUAGCAGGAAUUUGUGUCAUAGAAAUAGUGGGGGCUGGCCAGGCACAGCGGCUCAUGCCUGCAAUCCUAGCACUUUGGGAGGCCGAGGUGGGUGGAUUACUUGAGGUCAGGAGUCUGAGACCAGCCUGGCCAACAUGGUGAAACCCCAUCUCUACUAAAAAUUAAAAAAAAAAAAAUGGCCAGGCAUGGUGGCGUGCAUCUGUAAUCCCAGCUAUUCAGGAGGCUGAGACAUGAGAAUCACUUGAACCCGGGAGGCGGAGGUUGCAGUGAGCCGAAAUUGUGCCUCUGCACUCCAACCUGGGUGACAAAGCAAGACUCUGCCUCCAAAAAAAAAAAAAUGGAACAUGGAAACAUGGAAUGGGAGAAAAUAUUUGCAAAUCAUAUAUCUGAUAAGGGGUUCAUAUCCAGAAUACAUAAAGAACUGUUACAACUCAACAGCAAUAAAAACAACUCAAUUAAAAAUGGGCAAAGGACUUGAAUAAACAUUUCUCCAGAGAAAACUGUGAAUGGCUAAUAAUCACAUGAUAAGAUACUCAACAUCACUAACCAUUAAGGAAAUACAAACCAAAACUGCAAUGAGGCGCAACACUUUGGUGGAUCACCUGAGGUCAAGAGUUGGAGACCAGCCUGGCCGACACGGUGAAACCCCGUCUCUACUAAAAAUACAAAAAUUAGCUGGGCGUGAUGGUACGUGCGUAUAGUCCCAGCUACUUGGGAGGCUGAGGCAGGAGAAUCACUUGAACCUGGGAGGUGGAGGUUGCAGCAAGCCAAGAUCACGCCACUGCACCCCAGCCUGGGCAACUGAGUGAGACUCCAUCUAAAAAACAAACAAAACGCAAUGAGAAGAGAGGAUUUUGAAUGUUCCCGACACAAAGAAAUGAUAAACGCUUGAGGUAAUGGAUAUCCUAAUUACCCAGAUUUGAUUAUUACACGUUGUAUACAUGUAUUGAAAUAUCAUUUUGUAACCCAUGAACAUGUACAAUUAUGUGUCAACUAAAAAUAAAAGGAAUAAAACACAAUGAG

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