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Homo sapiens (human) long intergenic non-protein coding RNA 703 (LINC00703) URS000075F11B_9606

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LINC00703: LINC00703 is a long non-coding RNA (lncRNA) that has been found to play a key role in human gastric carcinogenesis [PMC6928083]. It acts as a competing endogenous RNA (ceRNA) by sponging miR-181a and regulating the expression of KLF6 [PMC6928083]. The full length of LINC00703 was amplified and subcloned into a mammalian expression vector for further analysis [PMC6928083]. The results of RNA immunoprecipitation (RIP) showed that both LINC00703 and miR-181a were enriched in Ago2-containing miRNAs, indicating their interaction [PMC6928083]. Further experiments demonstrated that LINC00703 suppressed tumor growth both in vitro and in vivo, suggesting its tumor suppressor role [PMC6928083]. Overexpression of LINC00703 decreased miR-181a levels and increased KLF6 expression, while knockdown of LINC00703 had the opposite effect [PMC6928083]. Luciferase assays confirmed the direct interaction between LINC00703 and miR-181a, leading to translational repression of KLF6 [PMC6928083]. The expression levels of LINC00703 were found to be decreased in gastric cancer (GC) tissues compared to adjacent normal tissues, showing a negative correlation with miR-181a levels [PMC6928083]. Additionally, the downregulation of LINC00703 was associated with poor prognosis and progression in GC patients [PMC6928083]. In conclusion, this study provides evidence for the regulatory role of LINC00703 as a ceRNA in GC by modulating the expression of KLF6 through its interaction with miR-181a. It highlights the potential use of LINC00703 as a prognostic marker for GC progression. Further research is needed to fully understand the mechanisms and clinical implications of the LINC00703/miR-181a/KLF6 regulatory axis [PMC6928083].

Genome locations

Gene Ontology annotations

Sequence

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AAUGUUUUUGCUCAUUAAUUCAGCAUGUAACUCACAUUCCAAUGGAAGCAGAAGAGGUUGAGCCCACAAUCAAACUGUCACUGAAUUCUAAACCAAAACUGAAGUAUGGACUUCUUCUCAUUAGGGUCACGUUGCCAGGACUAUACAAUGAAAUGCCUGGCCGUGAGAGUCCAGCAAUUUUCUUUGCUCUCAGAGUUCCUGUUUGGAAAAGAAAUCUGAGAACUUCAUGGUGAUGGACUUGUCCCUGGAAGAAUGUUAUGAAGACUGUGGUAGGACAGUGCAUUUGCUUCUCCUGAGGAUCUUGUUAAAUGAGAUUCAGAUUCAGCAGCUCCAAGAUGAGGAAGCCUGCAGCCCCCGAAGGUCACGGAUGCUGUUGGAGCCACGAGGAAGAGCCAUCAGCCCAGGGAGACCCUGAGGGUCAGGGCAUCUCCAUGGAUGAACUCCGUGUACUGCUGGACUCAUCCAACCCUUCGUGGACAUCACUUUGUAGUGAAAAUCCCUUUUGUUGUUGAAGAAAGCCUGAGUUGGGUGAUUUAUUACUCAUAAAGUAUGUUAAUACCUUGAUGCUAAUAUUCUCAUGAGAGAAUUAUACUCUAGUCUUAUGAUAGCACUAAAAGUAACUUAAAGGCCCCACGCUUCUCCAGAUAAAACCAACACUUGUGAAACCCUUGCUUUGCCGUUUACUAUCUAUGUUCCUGGACAAACUAUUAAAUGUGCCGAGUCUACACCUCCACCUCAGUUUAGGAUCAAUAAUCUAUAUCUUUUCUUUUUCAGUUUCAAUACAUAAAAAUAAGUGCCAUGAGUAGUUCUUGUAACUGAAUAGGCACUUAAAAGUGAAAUUAGGCUCUUCAUUUCUCCUGCUUUCUUAUCGUACAUCUUUAUGAUACUUUAAUUUGAGCUACAACCCCUGAGAUCUUCUUGAGAGUUAAUCACUGCUGAGAGACAAUACAGAGACAGGACAAUAGACAGAUCGCAUGUGACGACAGAGCUCUGACCCACAACCUCUGCAGCAAUUGCUCCCCAACAAUGGGGACUUAGUGAAUAACUGCUACCUGCCCUAUUUAUGCCCCCAACUCAGGAACAGCAGGUCAAUCCAAUAUGCUUCUCUAAUACCCACAUAGUUCUCAUUCUUUUAUUUUUAAUGUUUAUUUUGAUCUACAAUUAAAAUAACAGCUAACAAUCAUAGGUAUGCAUCCUUCAAUGCUUCCAACUUAUAAUCAUUCUUGUAUUAAGAAUUUUACUCUUUCAUUUUCCUGUGGUUGUUUUUUUCCCCUCAGGUUCUGCAAACACAUUUGUUGCCUAAAAUUGCACCUCUGAGAAAUUCCAGCACACUGGCAUAGUGUUCUGGACUCUCGCUGUGGUAUUACUGCCAGCACUAUGCUUCCUUAUUAAAAAAUGUAGAGGCUCACUUGCAGCAAGCUUGAUAGCAGGAUGAUAAAAUGGCAGGGUAUUUUUAAACACAGAUUUUAUGAGAUGUAUUACAUGGAAUUAAAUUUAGACCAUAUAUCAAGGAAAUCACCAUAGAGCUUUGAGCGUGAUUCAGAUCAUCCUGGCAUUAGUUGGACCACUCUGUUGGCUCAACAAUGUCAUUGCCUGAGUGGGAAAUAAAUGGCCAAGUCUAUGGGGGCACUAUCGGGUUGGCUUGCUGGUCACAGCAUCCUCCCCCCACAAGAUGUCUCAUCUGGAAGGGUAUGUAGGGCAGCAAUUGGUGGAAAUACACAGCAGAAGAAGAUUGUGACUCUUUCUCCAACACACCCCCUCCUCCUCAGUACACAACCUCUGCUCCCAAUGAUGGUACAAACAUCAGGGAUUUGACAGUACACACUCAAGAAACUGUUUUUUGGUGGUGUGUUUGUUUUUCUUUUUUCUUUUUUAGUUUGUUUUUGGUAGGAUCUAUCUAAAUGUAAGGUUAUUUUGAUGGUUAAUAUUGAAUGUCAACUUGAUUGAAGGAUGCAAAGUAUUGUUCCUGGAUGUGUCUGUGAGGGUGUUACUGAAGGAGAUUAACAUUUGAGUCGGUGAACUGGGAGAGGCAGACCCACCCUCAGUCUGGGUGGGCACCAUCUAAUCAGCUGCUAGGGCUGCUACAAUAAAAGCAGGCAGAAGAACAUGAAGGACUAGACCAGUUGAUUCUUCUGGCCUCCAUCUUUCUCCCAUGCUGGUUGCUUCCUGCCCUUGAGUAUUAAACUCCAAGUUCUUCACCUUUGGGACUCUUGGACAUUUGACCACACACUGAAGGCUGCACCGUCGGCUUCCCAACUUUUGAGGUUUUGGGACUUGGACCGGCUUUCUUGCUUCUUUGCUUGCAGACAGCCUAUUGUAAGACUUCACCUUGUGAUCGUGUGAGUCAGAACUCCUUAAUGAACUCUUCCUCAUGUAUACAGCUAUCCUAUUAGUUCUGUGCCUCCAGAGAACCCUGACUAAUACAGUUACACUCCCGGUCCGCAUUUGGGAUUCUGUAUGUAAACCUCAGAAUAAAUUCAACAAAAUUUGUCG

Taxonomic tree

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Publications