v24

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Homo sapiens (human) TOB1 antisense RNA 1 (TOB1-AS1) URS000075F043_9606

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TOB1-AS1: TOB1-AS1 is a long non-coding RNA (lncRNA) that is involved in the regulation of non-small cell lung cancer (NSCLC) metastasis. Microarray and bioinformatics analyses were conducted to investigate the mechanisms by which TOB1-AS1 regulates NSCLC metastasis [PMC6861872]. Additionally, the expression levels of six specific mRNAs were measured after silencing TOB1-AS1 in A549 cells [PMC6861872]. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that do not encode proteins but play important roles in various biological processes, including cancer progression [PMC6861872]. TOB1-AS1 is one such lncRNA that has been implicated in NSCLC metastasis. To gain insights into the underlying mechanisms, microarray and bioinformatics analyses were performed. These analyses likely involved examining gene expression patterns and utilizing computational tools to identify potential regulatory pathways associated with TOB1-AS1-mediated NSCLC metastasis [PMC6861872]. Furthermore, the expression levels of six specific mRNAs were measured after silencing TOB1-AS1 in A549 cells. This experiment aimed to investigate how the downregulation of TOB1-AS1 affects the expression of these specific mRNAs, potentially shedding light on their involvement in NSCLC metastasis [PMC6861872]. In conclusion, TOB1-AS1 is a lncRNA that has been implicated in NSCLC metastasis. Microarray and bioinformatics analyses have been conducted to explore its regulatory mechanisms, while silencing experiments have been performed to investigate its impact on specific mRNA expression levels [PMC6861872].

Genome locations

Gene Ontology annotations

Sequence

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GUGGGGGCAGACGUGCCAAUGAGAGAGAAAGGGGUGGGGUAGGGCGGCUGACGCCCGGUUUAGGCGGAGAGCGCCGGGCAGAGGGGGAGGGGGACGAAGCUGGUGGCGAAGCGGCUCAGGAGAACCGGGGCUGGAGGAGCGGCAAGAGUACCCAGAAAGUGCCCUCUCCGCGGGGGUCUGCGGCCAAGGAGGAUCCUGCUCGUGGAAUAGCUACCAAAUCGGCCUCCAGCCCACCCCAGGGGCGGGGUAGAGAAAGGGCAAACUGUGACCGGGACUUGUGCACCCGAUUAAUUGAAUAUUAAUCACCCCAAGGCCUAGGCCAACCGCCACCCAGAGAGUGGCAGCUGCAGAACCCAAAGACGUGGAGCCGGGCUGGGGGUGGGGAAGGGAGGCCGCCACAGCUCCCGCCCCGCCGGCAGUUUAACUGCUUCCGCAGCCUCAGGCCUCCCGGUGCGACCCCGGCUGCGACUCGGAUCCGUUUAUUCCAAAUGUCCCAGCCCACGCCGUGCCCAGAGUGUGGCGACACGAGGCCAAACUGCGUAGCAACGACGCCUGAUUGGCUGCGCUGGUCCCUUCGCAACGAGGCGAUUGGCUGCCUGGUAUCCAGGAGACCGACGUCAAACUCGGACUGGGAAAAGGGGAAAGUCUGGGGGGAGCGAAGGAGGGGACGGGGAGAAAGAAGCAAUGAAUGAAACGCCCAUCGCCUGGCCUUCCCCUUUCCCCUUUCCCCUCUCCUCUCCAUUCUUGGAGCACUUCCUGGAAAAACACCAGUUGGGGCGCCGCCUUCCCCUCCAAACGUUGGGGCCUGCACUCUCAACCUGCUAUAAGGAAGUUAAACCGCAGCUCACCGAGGAGUAGGGUGUCUACGGGGCGGGCCCGUGUAGACCAGCUGUGCUCCUCGGGCACAAACCCGCCGUACAUGCCAGGCCUAGAAGCUUUUGGCUUUGUGGACGCAAAAUCUGGUUGGAGCCGCCUUCUCCACCCUGACUCUCCCGCCUCUCCUUUUUAGAAGGAACCGCACUGAGAAAGGGUAUUUCUGAAGGCUCAAUGCGUAGGAGAAGGGGUGGGAAGAUGGGUUUGUGGAAUGGGCUGAGGGUGGGGAGUGGUCAGGUGACUGAUUUCAUGUUUAUUGUACAGAUUCCUAAAACAUAGUUUUACUAAGUGACUCCUUAAAUUCUGAUUAAUGUGAUUUUUUUUUUUUUUUGAGUGUUUGGGUUUUUUAGUUGCAAACAGGAGUGGAAUUGAAAUGUGAAAGUAUGGCAAAACUGUGAAAGCAUUUAAAUUAAAAUGUCCCUUCCUCUGCAUUGAAAUGUCAUCAAAGCGUCAAAUAUAAAUGAUUUGUUCAGUUUUCUUUUUUUAUUUGUUUGUUUUUGGUUUUCUGUAAUGACAAGUCCAUCUGUAAUAAAAGUGAGUUAAAAAA

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Publications