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Homo sapiens (human) PRKCA antisense RNA 1 (PRKCA-AS1) URS000075E50B_9606

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PRKCA-AS1: PRKCA-AS1 is an antisense long non-coding RNA (lncRNA) transcribed from the second intron of PRKCA [PMC8806685]. In a study, it was observed that blocking the p38/MAPK and TGFB1 pathways enhanced PRKCA-AS1 transcription, while inhibiting these pathways caused a reduction in PRKCA expression [PMC8806685]. The fourth exon of PRKCA-AS1 was found to be important for its interaction with DNMT1 [PMC8806685]. The full length and truncated forms of PRKCA-AS1 were synthesized and cloned into a plasmid [PMC8806685]. The transcription of PRKCA-AS1 was found to be positively correlated with DNA methylation at the promoter and first exon of PRKCA in vivo and in vitro [PMC8806685]. The interaction between PRKCA-AS1 and PRKCA was confirmed by FISH assay, suggesting that they may recognize a certain DNA motif through a complex loop structure [PMC8806685]. Additionally, Smad2 was found to occupy the upstream region of PRKCA-AS1 at the second intron of PRKCA in suppression of p38/MAPK and TGFB1 pathways [PMC8806685]. Over-expression of truncated forms of PRCKA-AS1 improved DNMT1 recruitment and DNA methylation levels on promoter and first exon regions of PRCKA [PMC8806685]. Furthermore, over-expression of PRCKA-AS1 resulted in down-regulation of mRNA expression levels for TNF-alpha treated cells, suggesting an anti-inflammatory effect [PMC8806685]. Computational examination indicated that the promoter region of PRCKA is included in putative genomic targets for PRCKA-AS1 interaction [PMC8806685].

Genome locations

Gene Ontology annotations

Sequence

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AUGGACAGGGUAGAUCUCAGACAGACAAUCCACAGUGAGGUUUCUGGCACCCGGGGUGUGCAGUCCACACACAGGAACAGGAUGUUUCCAGCAGGAGGAGGAAGCACAAGGUUACACAGGCUUCAGAGUCAGGCUGCCAGGGAUCAAAUCCCAGCACCUCCUUUUUCCUGUGAUGGGGCUUGUUCAACUUCUUUGAUAUCUCUAAACUAGGGAUAACAACAGCACCCGCUUGAGACUAUUGGGUGGAUUGACUGAACUCAUCUAUGUAAAAUGCCCAGCACACAAUAAGCUUCAUCAGCUGUUAUAAUUAAGAUGAGGAAGCAGACGCAAAAAAGGCAACCAGGCAAAGUCCCUAUCGCCCAACCUACCCAGAAACCAACAGACCCCAGGGCACUUCGAGCUGGAAAGGGCUAGAAAGCUUACCACUUUUUUUUCUUUGAAGCUGAACACUUCUUUGAACGCUUUCUCUAACAUCGAUUUAAGGAUAUCUUUGAUCUUUGUGGAAACAAAGAAGAAUGCUUUAAGACUGCGCUUAGAAAUCUGGCCGUUUGGUUUUAAGGUCAUUGGCCUCUGCCUACCGUGCUCCUGAAUGAAUAGCUCAGGACUUCCAGGGCUACCUUUGGGCCAAAAGUUAAUAAUUUACAGCUGAGCAAGUGUAGGUAAACUGCCACUUUACAGCAAGCUUCUAAUCCCUCACUGAUCACUUUGAAAAUUACAAAGGACAUUCACUUCAAGUGUGAGCCAAUUCAGAAUCAACCUCAUGCUAAUUUGAUAUAAGCUGUUCACUGAGGGAAAAAGUCCAAAGGAGGUUCUAACUUAUUUUCUAAAUGGACAUCGUAUCAAAAUUAAAAAUUCAAUGACAGCAUCUUUUAGCUCAAUCAUAGUUAAGUAUAUAAUACUGCUGAAUUUAAAGUCAGCAGAGAUUAUCUAGACUUUACUAUGAAAUAUAGACAAGCUGUGCUUUUAAAAGGUUUAUUUAAAUUACUGAUUAUAAAAGUAAUCCAAGCCCAUUUGUGAAAAUUUGGAAAAUGUGGAAGAGUAUAAAGAAAAAAAAAACUACUCAUUCUAUGAGCACCGAGAGAUAAACGUUAUCAUGUUGGCGCACUUCCUUCUGGCCUUUUUCUCCAGAUCAGAGGAAGAGGAAGGGUGGUGUAUCUUCAUGAAACUACUAACCCAAACCCAGAACACAGCCAUCUCGCUACUAAAGUCUCAGAGAUAUUGAGCUUGGACUUCGACCAUGGGUUCUGGAGUCCAUUCAAUUCCCAGCCUUGGCCAUUCCUGGCUGUGUAAUUUCAAGGAAAUUACCUAAACACUCUGAGUUUUGAUUCUAUCGUCAAUAAAAUGAAGGAAAUGCUAAAAAAAAAAAAA

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Publications