hsa-mir-1202: Hsa-mir-1202 is a microRNA that has been reported to be down-regulated in patients with depression [PMC4867432]. This down-regulation suggests that mental state may contribute to changes in the profile of circulating microRNAs [PMC4867432]. Anova analysis has shown a significant difference in the expression of hsa-miR-4270, hsa-miR-1225-5p, hsa-mir-1202, hsa-miR-1207, and hsa-miR-1290 based on the stage of cancer [PMC4867432].
MIR1202: The DE miRNAs in cluster 4 included MIR1202, MIR1207, MIR1243, MIR1246, MIR1307, MIR1469, MIR1915, MIR2861, MIR3130, MIR3143, MIR3178, MIR3191, MIR3196, MIR3202, MIR320A, MIR320E, MIR3613, MIR3621, MIR3665, MIR3667, MIR3679, MIR3684, MIR4261, MIR4267, MIR4280, MIR4281, MIR4330, MIR494, MIR500B, MIR514B, MIR550, MIR560, MIR638, and MIRLET7A2 [PMC8235499]. The nearby gene rs213382 is not linked to MIR1202 [PMC8718598]. The rs140092351 locus, located on MIR1202, has the most significant association with COVID-19 and interacts with multiple exposure factors [PMC7801182]. MIR1202 directly targets Rab1a and overexpression of MIR1202 inhibits the activation of the TLR4/NF-κB inflammatory signaling pathway, exerting neuroprotective effects [PMC9585453]. In exosomes, MIR1202 exhibits a 45-fold increase and is enriched in mesenchymal stem cells (MSCs) [PMC4598952]. In depressed patients, blood MIR1202 levels are inversely correlated with treatment response to antidepressants [PMC8999364]. Additionally, miR101, miR548b, miR554, and miR370 are potential therapeutic targets in PCNSL patients along with MIR1202 [PMC9428130]. A fusion transcript between RUNX1 and a sequence near the MIR1202 locus has been identified in t(6;21) chromosomal translocations [PMC5055202]. Furthermore, vesicles containing MIR451, MIR630, and MIR638 repress TLR expression to mitigate mitochondrial-transfer-induced inflammation caused by excessive mtDNA in macrophages [PMC8548694].