v27

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Homo sapiens (human) FGF10 antisense RNA 1 (FGF10-AS1) URS000075E1B4_9606

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fgf10-as1: FGF10-AS1 is a non-coding antisense RNA that is implicated in the regulation of FGF10 expression [PMC7333592]. This lncRNA has been found to be expressed at low levels in triple-negative breast cancer (TNBC), suggesting a potential role in the disease [PMC7333592]. FGF10-AS1, along with other lncRNAs, has been associated with the prognosis of TNBC, indicating its significance as a biomarker [PMC9221286]. The expression of FGF10-AS1 is notably low or undetectable in certain breast cancer cell lines, which may reflect its involvement in cancer biology [PMC5065698]. Despite sharing a bidirectional promoter with other genes and lncRNAs, FGF10-AS1 promoter activity was not affected by the transcriptional enhancer "Ref PRE" in specific breast cell lines [PMC5065698]. Furthermore, FGF10-AS1 has been identified as one of the hub lncRNAs and included in a risk score (RS) formula that may have prognostic value for TNBC patients [PMC9465033]. The expression levels of hub lncRNAs like FGF10-AS1 have been found to be higher in patients with worse prognosis [PMC9465033], and its association with other members of the FGF/FGFR family underscores its potential role within this signaling pathway [PMC9465033]. Lastly, studies have confirmed that FGF10-AS1 is associated with TNBC prognosis and included it within prognostic signatures for gastric cancer (GC) and TNBC [PMC8806586; PMC9955037].

Genome locations

Gene Ontology annotations

Sequence

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UGGAAGGGUAAGACCCGAUGCAAGGCAAGGAGAGAGCUCGAGGUGGUGGCUGCUGGUUAGCUCCCUCUGGGCGCGGAUCUGGCCAGAAGUGAAUGCACCAACAUCCAUAACUCCUCGGAAAAGCCGGCUGACUCCCCUCGCUCCUUUCUCGGAUCCGCUGCCUACGCCUCUGGAGCCUCCCGUGCCUGCACCUUUGUAACUGGUUACUUUAUUAAAGUCUCUUCACUUAAAUCAACUGGGAAGAAUUCUGUCCUACUCAGGACACUAACUUCAAACUGCAGUAUAUACCAUCACAGCUUCUUUGGUUUGACAGAACAUUUGGACACAUUUCUGCAAACGGACCCUUGGCAUCUCUUCUUGGAACAAAAUUUUGUAUUUGGACUCUGGCACCAUGCACCACAGAUGCAAGCAAGAAGCACUUCUACCUUCUGAGGCGGCCCCUCAAACUCAAGCCAGCUAGGCUAGGCCUGUCCAGCUUUCCUUCACAAAGAAGGAUUGGAGAGUUGCCGCUUACUGGCUUUCUCAAAUGUCAUUACUUAGCCAGUCUUCUGAAGAUUGAGAUUCAUGAACAUUGGACUCUUGCCUGUAAUUACAAUUCUUAAGUAUAUUAACCUUAUUUUCAGCUGUAUUUUUAGUUGCUUUCUGACUUCAUCUUGAAAAUACCUAUACUCUUUCUGCAUUUAUUCUAAUCUUACUUCUGAUCUUGAUUUUAAAAAGAUCUUUAUCAAUGAAAUCACCUCCAAGAACUAUUUUUGAACUUUAAGAUGUAUUCUUAAAUUUUUAGUAAAAUAGGAUUUAGAAUCAACUUUGUGAAGAUUACUAACAGAAAAAUGAAUAGCUCCUACCAUGAGGCAGUUUAUAGUUAAUGUAAAGAAUAUUAUACUUGUUUAUACAUGAAAAAGCCAUUUUCUUUCUCUAAACCUCAGAGAGCUAUAUAUAUUUAAUGAAUAAAUGAAUGUAUGAUGAAUGAAUUCCUGUCAGUCUUUAGCGAAGUCUUAUCUCUUAUUUGGAAUUCUUUCUUUAUCCCCUAUGUCUUCAUAAAUUCCAACCAAUAUCCAGGAUUAAUUCAAAUUCCUUACAAGGAUCUGAGAAGGGUUGGAGCUGUGGUAUGGGUAUGAUUGGUAGAUAGUUUUGAGCAACACUAUCACCAGAAAAUCUCUAUUUUUCUCCCAGUGACUUUUUGUUGAGGGUUGAAGAGUUUCCUUGAAGGCAAAAAAAAAAAAACUGUACUCAUCCAAAAUGUUACAGAUGUAACUUAUGGUUCAAUAGAAGCCUCUGCAAGCCAGGAUACAGAAAGAAACUUGAACCUUUGCAGAAGCUUGCAGAUUCAGCAACAGAGACUGAGAUAAGAAUGAAAUGGUAAUUCUGGGUAUGGUGUGGUGCCAAGUCCUGAAACCAGUCCCAAUAUACCUACCCUAGAAGCAUGUGGACAUCCUGAGGACAUGAAGGGCUCUAUGUGUGAUCCGGAAAAGGUGUUCCACUAUAUUCUAAAGUAUUUAUGGGCUGUGGUAGGCAGAGAAAAUUAUCCAGCAAAAAUUCAUGAAUUGUUACUGAAAAGUGACUUCUCAGAUAAGUAUUACAUUUCUCAGCUCUCGUCGUCAUUAAGCAUUACCAUGGUGACUCAGAUCUAUCCAGUGGAAUAUUGUAAGAAGUGAUGUUGCUAUUCAAGAUCUGGCUCAUGGAAGUGCUCCUCUGUGAUCUUCUCUCUUUUUUUUCUGCUGCCUAUAAUAAAAACUUCUCCCAGGGAACUUUGGAAGUCUCAUGCAGAAGACAGCAGAAACUUCACCAAUCUGGGUCUCUGUGUGACUGAAAGUAUAAGAGAUGGCAGACCCAUCUACCUGUUCUCUCACCUUUUAGUGUCACAUGAUCAAGAAAUACACUUCUAUUGUCGAGAAAAAAAAAAAAAAAAAAAAAAAAAA

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Relationships

Molecular Relationships

 Publications