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Homo sapiens (human) FGF10 antisense RNA 1 (FGF10-AS1) URS000075E1B4_9606

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FGF10-AS1: FGF10-AS1 is a non-coding antisense RNA that regulates the expression of FGF10 [PMC7333592]. Low levels of FGF10-AS1 are associated with triple negative breast cancer [PMC7333592]. FGF10-AS1 is one of the lncRNAs associated with TNBC prognosis [PMC9221286]. FGF10-AS1 expression is either very low or undetected in certain breast cell lines [PMC5065698]. FGF10-AS1 is part of a bidirectional promoter shared with the lncRNA BRCAT54 [PMC5065698]. The "Ref PRE" enhances the transcriptional activity of FGF10, MRPS30, and BRCAT54 promoters, but has no effect on the FGF10-AS1 promoter in certain breast cell lines [PMC5065698]. The expression levels of FGF10-AS1, along with other lncRNAs, are used to establish a prognostic formula for breast cancer patients [PMC9465033]. The expression levels of DIRC1, FGF10-AS1, MIR2052HG, and POU6F2-AS2 are high in patients with poor prognosis [PMC9465033]. Some members of the FGF/FGFR family are located near these lncRNAs [PMC9465033]. The prognostic value of FGF10-AS1 has been confirmed in triple-negative breast cancer patients [PMC8806586]. A 5-lncRNA prognostic signature for gastric cancer includes FGF10-AS1 as one of its components [PMC8806586]. Other lncRNAs associated with TNBC prognosis include FOXCUT and LINC00299 among others  [PMC9955037].

Genome locations

Gene Ontology annotations

Sequence

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UGGAAGGGUAAGACCCGAUGCAAGGCAAGGAGAGAGCUCGAGGUGGUGGCUGCUGGUUAGCUCCCUCUGGGCGCGGAUCUGGCCAGAAGUGAAUGCACCAACAUCCAUAACUCCUCGGAAAAGCCGGCUGACUCCCCUCGCUCCUUUCUCGGAUCCGCUGCCUACGCCUCUGGAGCCUCCCGUGCCUGCACCUUUGUAACUGGUUACUUUAUUAAAGUCUCUUCACUUAAAUCAACUGGGAAGAAUUCUGUCCUACUCAGGACACUAACUUCAAACUGCAGUAUAUACCAUCACAGCUUCUUUGGUUUGACAGAACAUUUGGACACAUUUCUGCAAACGGACCCUUGGCAUCUCUUCUUGGAACAAAAUUUUGUAUUUGGACUCUGGCACCAUGCACCACAGAUGCAAGCAAGAAGCACUUCUACCUUCUGAGGCGGCCCCUCAAACUCAAGCCAGCUAGGCUAGGCCUGUCCAGCUUUCCUUCACAAAGAAGGAUUGGAGAGUUGCCGCUUACUGGCUUUCUCAAAUGUCAUUACUUAGCCAGUCUUCUGAAGAUUGAGAUUCAUGAACAUUGGACUCUUGCCUGUAAUUACAAUUCUUAAGUAUAUUAACCUUAUUUUCAGCUGUAUUUUUAGUUGCUUUCUGACUUCAUCUUGAAAAUACCUAUACUCUUUCUGCAUUUAUUCUAAUCUUACUUCUGAUCUUGAUUUUAAAAAGAUCUUUAUCAAUGAAAUCACCUCCAAGAACUAUUUUUGAACUUUAAGAUGUAUUCUUAAAUUUUUAGUAAAAUAGGAUUUAGAAUCAACUUUGUGAAGAUUACUAACAGAAAAAUGAAUAGCUCCUACCAUGAGGCAGUUUAUAGUUAAUGUAAAGAAUAUUAUACUUGUUUAUACAUGAAAAAGCCAUUUUCUUUCUCUAAACCUCAGAGAGCUAUAUAUAUUUAAUGAAUAAAUGAAUGUAUGAUGAAUGAAUUCCUGUCAGUCUUUAGCGAAGUCUUAUCUCUUAUUUGGAAUUCUUUCUUUAUCCCCUAUGUCUUCAUAAAUUCCAACCAAUAUCCAGGAUUAAUUCAAAUUCCUUACAAGGAUCUGAGAAGGGUUGGAGCUGUGGUAUGGGUAUGAUUGGUAGAUAGUUUUGAGCAACACUAUCACCAGAAAAUCUCUAUUUUUCUCCCAGUGACUUUUUGUUGAGGGUUGAAGAGUUUCCUUGAAGGCAAAAAAAAAAAAACUGUACUCAUCCAAAAUGUUACAGAUGUAACUUAUGGUUCAAUAGAAGCCUCUGCAAGCCAGGAUACAGAAAGAAACUUGAACCUUUGCAGAAGCUUGCAGAUUCAGCAACAGAGACUGAGAUAAGAAUGAAAUGGUAAUUCUGGGUAUGGUGUGGUGCCAAGUCCUGAAACCAGUCCCAAUAUACCUACCCUAGAAGCAUGUGGACAUCCUGAGGACAUGAAGGGCUCUAUGUGUGAUCCGGAAAAGGUGUUCCACUAUAUUCUAAAGUAUUUAUGGGCUGUGGUAGGCAGAGAAAAUUAUCCAGCAAAAAUUCAUGAAUUGUUACUGAAAAGUGACUUCUCAGAUAAGUAUUACAUUUCUCAGCUCUCGUCGUCAUUAAGCAUUACCAUGGUGACUCAGAUCUAUCCAGUGGAAUAUUGUAAGAAGUGAUGUUGCUAUUCAAGAUCUGGCUCAUGGAAGUGCUCCUCUGUGAUCUUCUCUCUUUUUUUUCUGCUGCCUAUAAUAAAAACUUCUCCCAGGGAACUUUGGAAGUCUCAUGCAGAAGACAGCAGAAACUUCACCAAUCUGGGUCUCUGUGUGACUGAAAGUAUAAGAGAUGGCAGACCCAUCUACCUGUUCUCUCACCUUUUAGUGUCACAUGAUCAAGAAAUACACUUCUAUUGUCGAGAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications