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Homo sapiens (human) HLA complex group 4 (HCG4) URS000075DFE6_9606

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HCG4: HCG4 is a long non-coding RNA (lncRNA) that has been found to associate with various genes, including HLA-G, HLA-A, and HCG9 [PMC3628506]. In a study by Liu et al., RNA-sequencing data from The Cancer Genome Atlas (TCGA) database was used to identify a 9-lncRNA combination that could distinguish between high-risk and low-risk groups in terms of overall survival (OS) ratio [PMC7535691]. HCG4 was one of the lncRNAs in this combination [PMC7535691]. Another study identified a five-lncRNA signature that included HCG4, as well as NEAT1, RFPL1S, CBX2, and CDCA 8 [PMC7416381]. In the same study, a three-mRNA signature was also identified [PMC7416381]. HCG4 has been previously detected in non-coding genes identified in various studies [PMC6453468] [PMC9456698] [PMC9456698] [PMC9534503] [PMC9534503] [PMC9534503] The expression levels of HCG4 have been found to be significantly higher in certain conditions such as laryngeal cancer recurrence and preeclampsia placentas compared to controls[ PMC9219905][ PMC9219905][ PMC9219905][ PMC9219905][ PMC6522811][ PMC6522811]. Additionally, the dysregulation of HCG4 has been observed in recurrent laryngeal squamous cell carcinoma[ PMC6522811][ PMC8466298]. Overall, these studies highlight the potential role of HCG4 as a biomarker for various conditions and its association with different genes.

Genome locations

Gene Ontology annotations

Sequence

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CAAGGAGCACAGGUCCUCGUUCAGGACGAUGUAAUCCUUGCCAUCGUAAGCAAGCUGGUGAUACCCGCGGAGUAGGCGCCCGUCCGACCCCACGUCGCAGACAGACAUCCUCUAGAUGGGUGUGAGACCCUGGCCCCGCCCCCGCGGCCAGCCCCGCCCACCGAGCCCCGCCCUCGCCAGGACCAACCUGCGGGGAUUUUGGCUGAAAAUGAAACCGGGUAACGGCUCCUGGGCCUCUCCCGGGUCAAGGGUCUCCAGGUCCCGCUGCCUCGGCGUGGAUCUCGGACCCAGAGACUCGGGGAGACCCGGGCGGUCCGUGGGGGAUGUGGAGGGGUAGUGACCUGCGCCCCCGGCCGGUGUCACUCACAGGCCUCACUCUGGUUGUAGUAGCCGCUCAGGGUCCGCAGGUUCACUCGGUAAAACUGUGCUUUGGCCUUGGCGGUCCCUGUCUCCUCUUCCCAAUAUUCCGGCCCCUCCUGCUCCAUCCACGGCGCCCGCGGCUCCAUCCUGGGACUCGUGGCGUCGCUGUCGAGCCGCACGCACUGCGUGUCGUCCACGUCGCCCACGGAGAGGAAGCGGGGAUCCGCGCGGCCGGGCCGGGACAUGGUGGUGUGGAAAUACCUCAAGGAGUGGAAGCCUGGGAGCAAGGAGGGGGCUGAGACCCUCCCGACCCUCCUCCCGGCACCGCAACCGGGUUCCUGCGCCCCCGCCGGGCAGGCCCCUAGCUACUCCCCACAGACGCCGUUUCCCUCCCGACCCCGCACUCACCUGCCCAGGUCUGGGUCAGGACCAGGGCCCCCGAGAGCAGCAGAAGCAGGGUUCGGGGCGCCAUGACACCAUCCUCGGCGACUGGGAAGAAUCGGAGUCCCGGUGGGUGCGUGGGAACUUUAGAACCGGGACCGCGGCUACAUUGAUUGGCUUCUCUAGAAACCCGACACUCAAUGGGAGUGAGAACUGGGGCAGCCCGGUGAGUACCCAGGAAGAAGGACCCGACACAGGUUGGGAGAGGGAGAAGAGAAACCCUGCAAAGAUGGGGAAUGCCCAGCGCUGGGCCUCCCCAAUCCAUACACCGCCUUUGGGGCCUGAGAUCCUGAGAGCCACGCCUGAGGCCCUGGGACUUCGCCCUGACCCCGCUACUUCUGUGCCAAGCGCUCUGUCUCAAUGUUUCCCUGAGUCUUGGCCCAGGAGCUGUCUGAGAAACCAGGGAGAAACCCUCGGAAUGGGCCCCGUCCCUCUCUCUUCACUUUGCAUCACGGAAUCCCCGUCCCAGAACUGGACUCCCUGCCUCCUACUCCUUACCUGUCCCCGUGGACUCUUCUAGAAGAAAAAUCACCCCAGGGAGCUUGUUGCCAGAGAGUGAGCUUGCCCUGGGAAUGGAGGUGUAGAGACAGGGUUUUUUGUUGUUGUUGUUUGUUUGUUUUUUAAAUCUGGAAAAGUUGUGCCUGAGUGCAUGAGAUAGAAUAGAGACCAGUUUGCUUUUUGUUUAUUAACUACAGUGGGUAGCAGAAUCUUGGUAACUCCUAAUGAUCAGGAAUCUAAUCGGCCAAAAAUGUGACUUUGGUCCCUUGACAUAUAAAUGUGUCUAAAAGCAUUACAACAGGAAUCACAAAGCUCCUAAGUUUCACUUUCCCAGACAAUGUAUCUGUGACUCCCGCUUGUAGUAUUUUAAAUUUACCUUCAUUCCAUAGCCCUGAGUUUCUGUGUGAGUCCAGGACAUCUCCUAAUACAAGGUAGCCACUGUGUUACUAUAUGUUGUAACCAGGAGCCAGUACGGACUUUAUUCAUCUCACAGUGGCAAGCACUCAAUGCAGUCACAAUGCCCCUCACCAGUGCUCAUGCACUGCCUGUUUUUAGGAAGUAUCCACUUCUAAGUGUUGUGUAUAUUUUAUAUGAACACUUAGUAUUUUUUAAACCUGAUUAACAUAAAAAAAUUAGUUUUUAGGCAGACCCACAUAAGGUAUUAAAGGCCAACUGCAAAGAUCACCCUGCAAGGCUCUGUAGAUUGAUGUAUUAAAAUAUAUAAAACAAUGUGUUUAAACCUGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

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Publications