MIR4686: MIR4686 is a microRNA that was found to be one of the most upregulated miRNAs compared to healthy controls in a study [PMC8898099]. It was identified as one of the 11 miRNAs in the studied population [PMC8898099]. A meta-analysis of data from non-Japanese ethnicities revealed that a SNP locus near MIR4686 was associated with the disease after Bonferroni's correction [PMC4738362]. This locus was found to be located upstream of KCNQ1 and not in linkage disequilibrium with another lead SNP within the KCNQ1 locus [PMC4738362]. Additionally, MIR4686 was identified as a common susceptibility locus for type 2 diabetes across different ethnicities, although the significance of the association varied among individual ethnic groups [PMC4738362]. Furthermore, in publicly available European GWAS data, the T2D risk allele at the MIR4686 locus was associated with an increase in fasting plasma insulin, although this association did not reach statistical significance [PMC4738362]. Overall, MIR4686 is an upregulated microRNA that has been implicated in type 2 diabetes and its association with fasting plasma insulin levels has been investigated [PMC8898099] [PMC4738362].