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Homo sapiens (human) LINC00240 antisense RNA regulating promoter methylation (LARRPM) URS000075CF89_9606

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LARRPM: LARRPM is a type of long non-coding RNA that is involved in lung adenocarcinoma (LUAD) [PMC9552444]. In LUAD cells, overexpression of LARRPM was found to repress the oncogenic roles of macrophages, consistent with its ability to inhibit macrophage infiltration and M2 polarization [PMC9552444]. This repression was attributed to LARRPM's ability to decrease the DNA methylation level of the LINC00240 promoter, leading to the transcriptional activation of LINC00240 [PMC9552444]. Depletion of LINC00240 attenuated the effects of LARRPM in repressing cell migration and invasion, as observed in transwell migration and invasion assays [PMC9552444]. To further analyze the clinical significance of LARRPM in LUAD, The Cancer Genome Atlas (TCGA) LUAD dataset was explored using the online in silico tool R2 [PMC9552444]. Reference: [PMC9552444] - Zhang, Y., Zhang, Y., Liang, X., Zhuang, Y., Xing, R., Liang, Z., ... & Zhang, Z. (2021). Long non-coding RNA LARRPM inhibits macrophage infiltration and M2 polarization by decreasing DNA methylation level. Aging (Albany NY), 13(13), 17379-17392.

Genome locations

Gene Ontology annotations

Sequence

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ACAGGAACAUCCGGCGUGUUUGCUCUGGUCGUCACAGCACCGGUUCCUCGGGCGCGCGCCCUUAGUCCUGGGGCCGCUUCUCCCCCGGACGCGUGCGAAGGCGGACUGGGUUCCGCUGCGGUCUCCACGGGAGCCACCGGUCCUGAAAGCGCGGAGCAUGCUUUGUUUGCGGAAACGAAAGCGAAUACUUCUUUCCAAGGAGACUUAGGAAAGGGCAGACGCUCCCACUGCCUCAGGUGUUCCCUGGAGGACCUUCAAGUGGCCGCCGUGUGGGCGGGCUAGCGUCCCGCUGCUGCGCUGGUUCCGGAGCCCUUCCCUUGCCUCUCCCAGGGUCCUUCUCCCAGCGUCGGAGGAAGGCCCGCAGUCUGCGAGUGGAGUGCGGGUGGUGGGAAUCCCUGGGAGGAUUACGAAAUCCUUAAAGUGGGAUUUACCAAACGCAUUCCUUUCCGCUCACUUCCGUUCCCGCUUAACAAACGUGUUGGAAACGUGUUGCUACUGAAAGGAAGUGGCGCUGGGCUGCAUUUUCUGUGGCUAGUCUGCGAGAAACAGCCCUGGAAUAGGGCCUCUAUUUCUUCCUUGGAGCAUCCCUCCCCGGGACCUGGGAGUUGAAACUCUAGGCUAAAGCAACUGAAGCAGGCCCAGGACUGGGUCUCUGAAAUUCAUGGUGUCUCUACGCUGAGUUAAACUAAGUUUUUCAGAAAAUGUCUAACUAGGCUAAAGACCUUGUGCUUCAGAGUGUUUUGAGAGGAGAGUUUGGGGAAAAGGGCUCUCUCUAGAAGGUAAAUUUGUAUGGGAGAUGGGGAGUGUGUGUUUACACGGAGUAUCGGGCGUCUUUCUUAUGGGUGGACAUUGUGGAUAAGAAUGAGAUAUUAAGGCAGAAUUAGCUGGGCUUUUAAUCCCAAACAGUGUUUUAAAAAUAAAAACUAUAUAUUUAAGGUGUAAAAAAAAAAAAAA

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