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Homo sapiens (human) long intergenic non-protein coding RNA 265 (LINC00265) URS000075CC82_9606

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LINC00265: LINC00265 is a type of long non-coding RNA (lncRNA) that has been identified as a potential cell-free biomarker for the diagnosis and treatment monitoring of acute myeloid leukemia (AML) [PMC9585262]. In osteosarcoma cells, increased expression of LINC00265 has been shown to promote wound closure [PMC9179024]. Additionally, overexpression of LINC00265 in renal cancer cell lines has been found to enhance cell proliferation, migration, invasion, and the growth of xenograft tumors [PMC8560060]. In osteosarcoma cells, LINC00265 has been found to facilitate cell angiogenesis by sponging miR-382-5p and upregulating Spermidine/spermine acetyltransferase-1 (SAT1) and vavguanine nucleotide exchange factor 3 (VAV3), leading to suppression of proliferation, motility, and angiogenesis [PMC9179024]. Furthermore, in gastric cancer cells, LINC00265 has been shown to stimulate cell proliferation by interacting with miR-144-3p and increasing chromobox 4 (CBX4) expression [PMC9179024]. These findings suggest that LINC00265 plays a role in various cancer types and may have potential as a therapeutic target or diagnostic biomarker.

Genome locations

Gene Ontology annotations

Sequence

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AGCGCAGAUCCUGCCGGCUCUGGACUAGCCGCUCAGCACCAGGGCGGAAGGAAGACGAGGCGAGGCAAGCGCCAAGCUUCCAUCCGGACUUCAAGGCCAGUGGCUGGGUCUGGUUUUCUCAACACGGCCUCCUAGUCUCCUUCCCGCUUGGGCAUCUGUUUUUCUUAUAUAGACCCUGAAGCCGCCCGUGAUGUUCUGUAAGCAGGUUCCGCUUCAGAAUCAGAGGUACUUAAGAGGGAACCUGGAUGCUAGACCUGCCCUUGCUGCUGGCCUCAGUUUCUUUACCUGUAAAACAGGGAUUUUGGAACUGUUAAAUUAAAUCAAACUUAAAAGAAUUACAACUUAAAGCUGCUGGAACUUUACAUGAUCCCGAGCCUUGAGAGGAAUGUGGCUAUGCAGCCUGAGUCAUGUGGCAUGCAGAUGCAACCUCUGCCUUUUUCCGCUGUAAAUAAUUAAGAAGACCAAGUAGCAUCCAAGAGUCACCUAAGCUGAAGAUUCCCUUGAGAACAAGUACUGUCCUGUGGUUUCAUGGCCUUUCUUCCAUUUGUGGUUCUUGCCAAGCGGAAUUUAAAUGACAUCUUAUCAAGAUGGAUAAACCCUAGUUUCCCAGUGCUGGAAUAUAGAAAAUGGAUGGACAAGUAAAUCCCACUCAGCACCCAUAGCCCAGGCAUGGGGACCUCAACACAUUUGAGCCGCAGAGAUCACCUUUCAUUGUGAAUAGCUCUGAGAUGAUACUUCUGGUUGAAUGUCUUUUUGUCACUUCCGGCUGGAUCUACCAUGAAAGAUUUCUGAAUCCAGGAAGAGAGAUUGACUGGGCAACAUGUUAUUCAGAAACAGGACCUUGCCCUGUCACUCAGGAUGGAGUUCAGUGGUCCAAUCAUGGCUCAUUGUAGCCUCAAACUCCCAGGCUCAAGCAAUCCUACCACGUCAGUCUUCCCAGUAGCUGACAGGGUCUCACUCUGUCGCCCAGGCUGGAGUGCAGUGGCAUGAUCUUGGCUCACUGUAGUGUAGACUUCCCAGCCUCAAGGGAUCCUCCCACCCCAGACUCCCAAGUAGCUGGAAUUACAGGUCUCAUGCUCUCACUCAGGCUGCAGUACAGUGGCACAACCUCUACUCACUGCAGCCUCUACCUGCCAGGCUCAAGCAAUUCUCCUGACUUAGCCUCCCGAGUAGCUGGGAUUACAGUUGAAGCAUAUGUCCUGUGAGCUUAGGGGUGCUACAAGUUGACCACUGCAGCAGUAAAGAUGAUUCUGAAGAAUGGCAUGGGAUGGAUCCUUUCGAAUGCACUUGAGCAGCGGUCUCCAACCACAGGGCCACAGAGCUGGAGCUGGAUCUACCAUGAAAGACUUCUGAAUCCAGGAAGAGAGACUGACUGGGCAACAUGUUAUUCAGGAGAUGGGGUCUCACCCUGUCGCCCAGGCUUGAGUACAGUAGUGCUAUCACAGCUCACUGCAGCCUUGAACUCCUGGGCUAAGGAUCCUCCUACCUGAGCCUCCUGAGUAGCUGGGACUGUAGGGUCUCCCUCUGUUGUCCAAGGCUGGAGUGUAGUAGUGCUAUCACAGCUGACUGCAGCCUCAACCUUCCAGGCUGAAGCGAUCCUCCCAUCUCAACCUCCCACGUGGCUGAGACUACAGGCGCUUGCCACUAUGCCCAACUAAUAUUUGGAAUUUUCCUAUACGUGGAUUCCAGAGGGGUGACAGCGAAACGUGGGACCAUCCAGUUGCAGGAAAACGAGCUUAACACGCCCACUGAUUCUACAUUAUGCUCCUACCUCCCGGCAGCCUCUCCAGGCCCAGAACUUUCUCCAGUCGGCCUCCACAGACCAAGCUCAUGACUCACAAUGGCCUAUUUAGGCCCAUACCCUACCUCACGGCAGUCUCCGCAGAUGAGGCUACUGCCUCACAACAGCCUCCACAGGCACAGCUCCAUCGUUACAAUGGCCUCUUUAGACCCAGCUCCUGCCUCCCAGCCUUCUCUCUAGGCCCUGAACUUUCUCAAGUCGACGUCACCAGGCCCAGCUCAUGCUUCUUGGCAGCCUCUCCAGGCCCAGCUCUUCCUCCCGGCGGCCUCUGCAGGCCCAGACUGUCAUCAAGUCGGCCUGUCCAGGGCCAGCUCCUGCCUCCCGGCGCCCUCUGCAGGCCCAAGUCGUCCUCAAGUUGGCCUCCCCAGGCCCAGCUCCAGCCUCUCGGCGGCCUCUCCGGGUGCAAAAGUUCCUCGAGUCAGCCUCUCCAGGCCCAGCUCCUCCUGCCUCCCAGUGCCUCUUUCGGCCCAGCCCAGCUCAUGCCUCUGGGCGGCCUUCCCAGGCCCCGCUUUUGACUUUUGGCGGCCUCUGCAGGCCUCGACAAGGCCCGGCCUCCUGCCUCCCGAAGCCUGCACAGGCCCAGCCUCUGCCUCACAGCAGACUCUCCACGCCCAGCUAGCUCUCGCCUCACUGCGGCCUCCCCAGUCCAAAGCUCCUGCCUCUCGGCCGCUUCGGCAGGCCCAGCUCCCGCCUGCCAGUGCCUCUUCAGGCCCAUGGGGCUCAUUCCUCACAACGGCCUUUCCAGGCCCCGUUUUUCCCUUCCGGCGGCCUCUCCGGGCCCAGAACCUCCUCAAGUUGGCCUCUCCAGACCCACUUGCACCCUCCGGGCGUCCUCUCCAGGCCCAGCUCUUCCUCCCGGCUGCGUCUCCAGGCCCGACUCCUGCCUCCCAACAACCUCUUUGGACUCAGUGCCUGCCCAUCUCCUGGCGGCCUUGGUCGGCCCACAGCUUCCUCAAGCCAAGCUCCCCAGGCCCAGGUCAGGCCUCACGGUGGCCUCUCCAGGAUCAGCUCCUGCCCUCCGAUGGUGUCUCCAGGCCCCAAAUGGUCUCCGGCCAGUGGGCUCCUCCACGCCCAGCUUGGGCCUCCCGGCGACCUCUGCAGGCCCAAGUCGUCCUGAAGUCGGCCUCUCCCGGCCCUGCCUCCCAGCAAGUAAGCAAGCUUUUUUGGCUUAGCUCCUGCCCAGCUCCCAACCGCCUUUGUAGGCCCCGAACUUUCUCCAGCCAAGCUCUUCGGGCCCACCUCCUGCCUCCCGGUGGCCUGUACAGGCCCAGCUCUGGCUGGAGAACAGCCUCUGCAGGCCCCGCUCUUGCCUCCCAGGGGCCUCUCCAGGCCCAGCUCUCGCCCCCACAGCGGCCUCCCGGGGCCAAGUCCCUGCCUGCCUCCCGGCAUCCCGCAUGCAGCCCAGCUCCUCCCUCACGGUGGCCUGUUGAUGCCCAACUCAUGCCUCUGGCACCCUGCCCAGAGGCGUGAGCCCCUGCCUCACACCGGCUCCUCCCACGCUGACAGAGGUCAGCGUGAGCCCCUGCCUCAACAGGCCACCGUGAGGGAGGAGCAGGGCCGCACGCGGGCUGCCGGAAGGCGGACAGGGACUUGGCCCCGGGAGGCCGCGGUGGGGCAAGAGCUUGGCCUGGAGACGCCCCUGGGAGGCAACAGCAGGGCCUGCAGACGCUCUUCUCCAGCCAGAGCUGGGACUGUACAGGCCACUGGGAGGCAGGAUGUGGGCCUGAAGAGCUUGGCUGCAGAAACUUUGGGGUCUACAAACGCCGGCGAGAGCUGAGCCGAAAGAGCUUGCUUGCUGGGAGGCAGGAGCUGGGCCGGGAGAUGCAGCCAGGAGGAACAGCUGGGCCUGCAGAGGCCGCCAUGCGGGAGGCAGAGGCUGGGCCUCCUCAAGUUGGCCUCUCCAGACCCACUUGCAGCCUCCCGGCGUCCUCUCCGGGCCCAGCUCUUCCUCCCGGCUGCGUCUCCAGGCCCAACUCCGGCCUCCCAACAAGGUCUUUGGACUCAGCUCCCCCGCAGCUUCCAGCGGCCCUGGUAGGCCCACAACUUCCUGAAGCCAAGCUCCCCAGGCCCAGCUCAGGCCUCACGGUGGCCUCUCCAGGCUCAGCUCCUGCCCUCCGACAGCGUCUCCAGGCCCCAAACGGCCUCCGGUCGGUGGGCUCCUCUAGGCCCAGCUUGGGCCUCCCGGCAGCCUCUGCAGGCCCAAAUCGUCCUGAAGUCGGCCUCUCCAGGCCCAGCUCCAGCCUCCCGGCGGCCUCUGCAGGCCUAAGUCGUCCUCAAGUCGGCCUGGAAAUGGGCCUGGAAGAGCUGCAAGUCGGCCUCCCCGGGCCCAGCUCCGUCCUCUCGGCGGCCUCUCCAGGUGCAAAACUUCCUCGAGUCAGCCUCUCCAGGCCCAGCUCCUCCUGCCUCAGUGGCCUCUUUCGGCCCAGCCCAGCUCAUGGCUCUCGGCGGUCUUCCCAGGCCCCGCUUUUGACUUUUGGUGGCCUCUUCAGGCCCAGAACUUGACCUCCAGUCGGCCUUUGCAGGCCCGGCCUCCUGCCUCUCGAAGGUCUGCAUGGGCCCGGCCUCGGCCUCACAGCGGACUCUCCACGCCCAGCUAGCUCUCGCCUCACUGCACCCUCCCCAGUCCAAAGCUCCUGCCUUUCGGCCACUUCGGCAGGCCCAGCUCCUGCCUGCCAGUGGCCUCUUUAGGCCCAGCUCAUUCCUCACAACGGCCUUUCCAGGCCCCGUUUUUCCCUUCCGGCAGCCUCUUGGCCUCUAAUUUUUUUAUCUUUUGUGUAUAAAUCCCAAAUUAUGGAAUUUUGGAAUAUUUCCACCAUUAUAUAAAUAUUUUGGUAGGUAAUUUAAAAAAAA

Taxonomic tree

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