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Homo sapiens (human) lncRNA activating regulator of DKK1 (LNCAROD) URS000075CC38_9606

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LNCAROD: As a scaffold for the interaction between Y-box binding protein 1 (YBX1) and heat-shock 70-kDa protein 1A (HSPA1A), m6A-modified LNCAROD shields YBX1 from proteasomal degradation by promoting the YBX1-HSPA1A protein-protein interaction, leading to HNSCC cell growth by stabilizing the YBX1 protein [PMC9641156]. The lncRNA activating regulator of DKK1 (LNCAROD) was shown to be stabilized by m6A methylation in HNSCC cells and suggested to be used as a scaffold to promote the YBX1–HSPA1A PPI and stability of the YBX1 protein, resulting in the cell proliferation and migration of head and neck squamous cell cancer [PMC8277384].

Genome locations

Gene Ontology annotations

Sequence

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UGAGCUGAAAUAUGAGUUGUCCAACUCUUGUAAGUGCAUGCUCCAUCACAUCAUCCUGAGUCAGUAAUGAGGAUGCCAUUGUACCCUUCAAGCAGCCCUGGAGAGUUUAUCUCUGCAUGCUGGAGCUAAUAAUAAUAGAAUCUCAAGAGCCUUCAAACAUCCAUAUUAUGCUGAUGUCUUUUAAGGUGAUUCAACUCAGCAUAUGUUGUUUGAAGCCGUGAGACUGAGUGAGAUCAUGGAGGAAGUGAAUGUAAAUAGAAAAGGGAAGAAGUCUGAAGACGGAGCCCUGAGACACUCCAUUGUAAACUGGAAGAUGAGGAAGAGCCAGCAAAGGAGACUGAGAAGGGGCAGCCAGUGAAGAUGGAGCCAGGGCUAGAGUAAGAGCCCCUUCUGGGAUGCUGUGACCCCCAAGUUUGAAGACUGCUGAUAACCCCAAUCUACGAAGACUAGCUAUGGAACUUCCUACACUGAGACAACUCCAGUGGAACUCUGAUAAUUAUCCUAAAAUAAGGAGGCUUCUUCAGUAGCCCUCGAAAUAUGUUCAAAUACAUGAUUACAUUUAUGUCCUUAAUAUUGCUAUUAGUUUCUGAUGUUAAUGUAAAAGUUGGGGAAAAAGUGGAAAAGUUAAAGCAGUGCAGGUUAAUUCAAUGCCAGAGUAACUUCUCAGAGGGUGUAUAUUCAGUGUGAACAAUUUUCAACAGAGAAAUGUCAACUUCUGGCCACAACGGCAACCAGUAAAAUGACUAUUUUUACUGUCUUAUCUAUUAAUGAAGAGGAGAUUGCAUAAUAUAGAUGAAGGAGCAUAGUAUUUGCAGGUGGAACGCCUAGCAGGGCUUGAGUCUCAACUCUGCUGCUUUUACUCUAAUUGACCGAGACAAGUCAUUUAAACUAAUAGAGCUUCAAUUUUCUCAUAUCUAAUGUAACAUAACAAUUCACAGCCUUUUACUUUGUAGUUAUCGUGAAGAUCUAAUCGCAGUGAAAUAUAUUUAUAUAUCUGUCUGCUGAUA

Taxonomic tree

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Publications