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hsa-mir-3941: Hsa-mir-3941 is one of the CoV-tar-miRNAs that target the 3ʹUTR of the SOCS3 mRNA [PMC8527307]. Transfection with hsa-mir-3941 mimic resulted in a statistically significant reduction in viral expression [PMC8201247]. The therapeutic upregulation of hsa-mir-3941 may be beneficial in reducing viral infection by directly blocking viral expression through 3ʹUTR targeting and inhibiting the PI3K/AKT pathway [PMC8201247]. The mutation in hsa-mir-3941 is rare and does not affect its binding affinity with other microRNAs [PMC8201247]. Hsa-mir-3941, along with hsa-miR-138-5p, has the potential to reduce viral pathogenicity in major variants of SARS-CoV-2 and SARS [PMC8201247].
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