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Homo sapiens (human) MAPT intronic transcript 1 (MAPT-IT1) URS000075C819_9606

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MAPT-IT1: MAPT-IT1 is a long non-coding RNA (lncRNA) transcript located in intron 1 of the MAPT gene [PMC4815063]. It is one of the genes internal to MAPT, along with the saitohin (STH) single exon open-reading frame in intron 11 [PMC9735940]. In brain tissue, MAPT-IT1 has been observed to be relatively elevated [PMC8157669]. The tissue-specific single nucleotide polymorphisms (SNPs) in AQP4-AS1, another lncRNA, predominantly occur in brain tissue, while the genome-wide association study (GWAS) SNP annotation for MAPT-IT1 is associated with Parkinson's Disease [PMC8157669]. A risk score calculation involving the expression levels of various lncRNAs, including MAPT-IT1, has been proposed for Parkinson's Disease prognosis [PMC9712677]. In a study on breast cancer prognosis and diagnosis biomarkers, MAPT-IT1 was found to be significantly increased in breast cancer and correlated with overall survival [PMC9596248]. Furthermore, a 10-lncRNA signature risk prediction model including MAPT-IT1 was developed for breast cancer outcome prediction [PMC7450318]. Although there have been few studies on the function of MAPT-IT1 so far, its potential as a prognosis biomarker for breast cancer has been further confirmed by these findings [PMC9596248]. References: [PMC4815063] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815063/ [PMC9735940] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9735940/ [PMC8157669] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157669/ [PMC9712677] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9712677/ [PMC9596248] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596248/ [PMC7450318] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450318/

Genome locations

Gene Ontology annotations

Sequence

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GAGGUGCCAUCUUUUUUCGGCGUGUCACGUCUUUACGGUGCCAUGCCAAACCGGGUGGCCGGGCUUCAUAGGACAGGGCGGGGCCUGGCAUUAAAGGGAGGGGGACAAUCAGCGCUGAAAUCUUGGCGUUUUGCUGCUGCGGGCGUGAGCACUGGGGGCGUUCGCCCAGCACCUUCUUCGGGGGCUCUUUGCUUUGUCUGUAGAGGUUACGUGAUCUGCGCUCCCAGCCCUGGUUUCUGGCUUUUAUUCUGAGGGUGUUCAGUCAACCUCCCCCCUACGCCCAUGCGCCUCUCUUUCCUUUUUCGCUCCUCAUUUCCGAGCCCAUUGUUGGAUCUCGAGGCUUGCUGGGUUCGAUGAACUCGAGUCAACCCCCCGACCCCCGGCACGCAUGGAACGGGCGUGACCGCGCGCAGCCUCGUCUCGGAGUCUGCCGGCGCCGGGAAGCUUCUGAAGGGAUGGGAUUCGAGUCUCCGUGCGCGCUGCGGGCGGCGGCAGAGGGAUCUCGCCCCUCCCUACACCCCAAGUGUCCUGAGGGCCACGCCACACCAGGUUGCCCAGCGAGGGACGCUGGCUACCCAUCCGGGGAUGGGUGGGGAGCCCUGGCGGGGCCUCUCCGGCUUUACGCCCUGUUGCUUCGCCUGGCCGGAGAAUGUGAGGAAGGGGCAUAAGGUUACUGGUGCUUCGGCCACACCCAUCUUUCUGAGCCCACUGGACUGGGCGCAGAGGGGGGAUUGCCAUGGAAACCACAGGUGUCCGGAGAGGGGAUCUUGGGGCUGGCCUCACCCCUUCCCUGCGGAGAUUGGGGACCCUGGGGUAGGGGGAGCCGCGCCCAGUCGGCCUCCUGGAGGACACGGGAGGAAGCCCCGAACCCCCGCGCCUGAGGCUGUUUCUGAUUGGCCCCUGGAGGCCGCAGACACGCAGAUAGGCGGCCCUGGGUGUAUUUUUAUUAAUAUUAUGUCCGUACUGAUUAAUAUUAUUUAUCUUAAAUAAAUUUCACCCGUGUCCAAGUUCACCGCGCCCCCAAAACCGAGUCUGGGGCGGCAGGGGGAACUCCUGGCCAACGAAUCCAUGCCUCGCCCUCCUGUGAUGAACCUGGUACGCACGGUUUUCUGGUUAAUUCUAUCGCUGAAAACUGGUGCGGGGGGCGCACUUCUGAGACGGAAGAGCAUCUAGGAGCUGAAUCCUCCACGCGGGUCGCCCAGGUUGAUCUGAAUUUCUGGGGAAUGGCUUGGCUGCCCGCCCGGGACCAGGCCGACCCUCCUUGACGGUGGCGUAGAGGGCUGGAGCCUGGGUACUGCGAGGCUCCUCGCAUGGCUGGGCCCGCCGCGAGGGGUUGCAGAGCGGCUCAGGGAUCGAUUCAAGCAUCGUCUCUCCUCCCUCGCCCCCAGACAGAGCUGGGCGCGGGGUUCCCCUUCCAGAUGGAGCGAGGGUCUCGGGGUGGCCCCGGAAAAGGGGAGCCCGCGGCCACGGCUACGUAUUGCCAUCUCGCGAGCAGAGAUGUCACCUCCUGCCUUUGGAGGAAAGGGAGCCCGGUGGGGAUGAGCGCAUUUAGCCCAAUGCUGGGAACAAAGCGCACUCCGCGCUUCUGCGAUUUCGCUCCAUUUUGAAAUGUGUUGGCGCUUUGGUGGGGCCGCUGCGGUGGGCAAGGCCGGGGGCGCUGUUAAUGGAGGAACCUCAGGGGGACGGUCCUUCGUAGGAAACUCUAUCCUGGCUCUGCGCGCGCUUUAAGGAAAUGGCUUCCCUCCAGGACCUCGAGGGAUGCAGCUUUUGCGCGGAUGACGGUGGGGUGCUGAACCAGCCGGUGCGCCUCUGGAAAUGUCUGGGCACGGAUCCUGGGGCCAUCGACGACUCCUCCCCAUUCCCAGCAGGCGGGAGCUCUUACAUUCCGAGCGAGUGACCCCUCUCACCCUCUGGCGCUCACACACCUGUAACUCCAAACCUCCGUCUCAGAAUGGUCCAGGCUGGAAGGGAUGAUGGGGGCUCCGACAGCGACUGCCUAGCUCACCCCUCUGCGUGCUCAGGCUCCAGGCUCAGCAGGACCAAUUUGAGUUCUAUCUGAUCCCCCUCGGCCCCUUAACUGACCCAUCCUACAGGAGACAGGGAAAUGUCUUUCCUACCGCGGUUGAUUCUGGGGUGUCAUUUUGUGUUUUGUGAUGGCUGCUUAUAUUUACUGUAUAAGCAUUGUAUUUACUGUAUAAGCAUUGUAUUAUAAUUACUGUAUAAGCUGCUUAUAUUUACUGUAUAAGCAUCUCCAAAUCCUCCCUCUACGUAAACAAAUUAAUGGAUAAACAGAUAAGUGUAUCCCCUGCCCCCACCCCUGCUACGCAGGUCCGGAGUGACUCUUGAAGCUCAUACAUUCCUUGGCCAAGUUUGCUUCUCUAACAGAUGUUUAUAUAGCAAUAACCUGGCUUGGCUCUUGGGUUCACCUUUGGACGAUUUGGGGAAGGGGCUUGUUGGCUUUGCUGGGUUUUGGAUGAGUGACAGUCCAUGACUGUUCCUGCUGGAAGGGCGUGACUUUUAAGUGGUUUCUAAUAUCAGGCAUUGCUCCUCCGACAGGAACAAAAGAAAUGGAUACUGCCCAUAAAUUGUUAGAAAACUUAGAAUCGCUUUGAUUGAGGAAAGGUUAGAUUUAUUCCGGUUGGAAAAAGUGGCCUUUCUAUUAAACGUGCCCUUUGACCCUCAUGCCCUUGGAGGUCGGUGCCAGCCUGGAGAUGGGAUAAGAUUGUGGUUUUCCUUCUGCCUUUUUAACAUCUGUUGUUACAGUCCAUUUGUUGAAAAUUUAAAGAAACUGUUUUAUUCCACUUUCCCUCAGCAUUUAUGUGUGUGGUUUCAGUAGCUCUGUGGCUAUAUGUACGAACACGUGUUAUUUUUCCAAUUGGACAUGUGAUAAUUUUCCAACUGGACCUUGCCUUCUAUUGAUGUAUUUAUUUAGCAUCUUCCUUACUCCCUCCUUGAAAAAGAAUCACUCAAAAACAAAUAAAAACAGCCGUAGGGGCCUAAUACAGUGCUAGACAUAAAAAAAAA

Taxonomic tree

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Publications