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Homo sapiens (human) HNF1A antisense RNA 1 (HNF1A-AS1) URS000075C27F_9606

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HNF1A-AS1: HNF1A-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including bladder cancer, esophageal squamous cell carcinoma (ESCC), lung adenocarcinoma, hepatocellular carcinoma (HCC), glioblastoma multiforme (GBM), cervical cancer, colorectal cancer (CRC), osteosarcoma, and gastric cancer [PMC9563963] [PMC4631113] [PMC4905504] [PMC4496209] [PMC5647038] [PMC5822613] [PMC8590016] [PMC8202880] [PMC8840784]. It has been shown to promote cell proliferation and metastasis in lung adenocarcinoma and osteosarcoma through various mechanisms, including interaction with DNMT1 and repression of E-cadherin expression [PMC4905504][PMC5412317]. HNF1A-AS1 has also been found to act as a competing endogenous RNA (ceRNA) for miRNAs such as miR-22, miR-34b, miR-124, and miR-30b-5p in different types of cancer to regulate gene expression and promote tumor progression [PMC8590016][ PMC7035897][ PMC8802127]. Additionally, HNF1A-AS1 has been implicated in drug resistance in cervical cancer and cisplatin resistance in gastric cancer through its interaction with specific miRNAs [ PMC8840784]. The expression of HNF1A-AS1 is often upregulated in tumor tissues compared to normal tissues and is associated with poor patient survival outcomes in GBM patients[ PMC8590016]. The functional role of HNF1A transcription factor on HNF1A-AS1 needs further validation[ PMC7581809]. The expression of HNF1A-AS1 can be regulated by other factors such as EGR1 and METTL3/METTL14 in gastric cancer and CRC, respectively [PMC8590016][PMC9562639]. HNF1A-AS1 has also been found to be involved in the regulation of the Wnt/β-catenin pathway, which is important for cell proliferation, migration, and invasion [PMC7912917]. The expression levels of HNF1A-AS1 can be detected in various cancer tissues and cell lines using qRT-PCR [PMC9562196][PMC4608159]. The functional effects of HNF1A-AS1 can be studied using knockdown or overexpression plasmids [PMC8202880]. The m6A methylation of HNF1A-AS1 has been observed in CRC cell lines [ PMC9562639]. The diagnostic potential of HNF1A-AS1 has been explored in ESCC patients using ROC curve analysis [ PMC4631113]. Further studies are needed to investigate the effects of genetic polymorphisms on the expression levels of HNF1A and its association with HNF1A-AS rs7953249 polymorphisms[ PMC9223288] [PMC9223288].

Genome locations

Gene Ontology annotations

Sequence

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AGUAAGUGCAGUAGGUAGGCCAAGAUAACUAUUAAGUAUGUCCUAACAAGGUAGCUGCUUGAAAAAAAUAAUGCACAUAAAUUAAAAAAAAAAAAACUAUUUUCACUCAUUCUUAACUUCUCGUAUGGAUGUACUAACGGGAGGCCUGUGCCUGUUGGGCUGUCCACAGCUACUCAAACCUUGAGAUUAGAUUGGACGCUAUCUAAUCUCAUUUCCUGUUACACAAUAACUUCUGCAUGGCACUUGCUUUUAAUCAUGACAACUGCCAUACACUCAGCUUUACAAAAUCAUGUCAUUGUGGAAAGGAAGUUCCCUCCAUCUAACAUUCAAAUUUAACUAUCCUGAGCUGGUAGUUUGCAAGGUGUCCAACAGAUGUCACUGUGUUUCCUUCGCAAAUUCUCUAAAAUAGUCUGCUGUGUCCCGGGGCAUAGUAGAUAUUCAAGAAAUGGUGGCUAUGAGUUUUAUCACAAUUCUCUCCUACUGGGUGAGCAGCUGUUUGCAAGACUAAAAUUCGGGCGAGGCACAGGCUUCCCCUUGGUCUUAGCAGCUAGCACAAGACGAGUGUCCCUUCAGCCAGUCUCAGAGCUCUUUGGCAAUUCAACUGACCCUUGUCCUUCAGUCCAGACAAUGCCCCAGGGCCCACCUGCAUUCAAACUCGGACUGUUCUCCUUCCCACCCCUAUUAUCUUUUCAACUUUAUGGACAGUACAUGCAAUUUUCUCAUUCAUUUUCUCAUUUAACAUCUAACAGCUUCAUGAUAUCCCCAUUUUACAGAUAAGGAAACCAAGGCUUUAAGAGGAUAGGGACCCUAAUCGGCUAAGGCAGAAUUAGGAUUUGAACCCAGAUCCCCAUGACGCCAGAAUCUAAGCCUUGACCAAAUAUGUGUUACUAUUACUUUUGUUGUUGUUGUUGUUCUGGGUAACUCCAACCCUCUGCUCGUUGGCCUUGUCACCUCAGUGCUGAUUUUGCAGAUGAAGAGACUAAGGUUCCGAGGUGCUAGAGCACAGUGGUUAGGAACACACACUCUAGAGCCAGAGUGCCUGGGUUUGAGCCUCGUUCUGCCGUUUACUAGCCGUAUGGCCUUGGGCAACUUGCUUAACUUCUCUUUGCCUCAGUUCCUCUUCUCUUGGGUUGUUAGGAGAAUGAAUGAGGUGAUAUCCACAGUGUCCAACACCCUGCAAGCGGCCAGGUGUGGUGGAUCACACCUGCAAUCCCAGCACUUUGGGAGGCCGAGGCAGGUGGAUCAUUUGAGGUCAGGAGUUCGAGACCAGUCUGGCCAACAUGGCGAAACCUCAUUUCUACUAAAAAUACAAAAAUUAGCCGGGCGUGGUGGCAAACAACUGUAAUCCGAGCUACUAGGGAGGCUGAGGCAGAAGAAUCGCUUGAACCCAGGAGACAGAGGUUGCAGUGAGCCAAGAUUGCACCACUGCACUCCAGCCUGGGCGACAGAGUGAGACCCUGCCUCAAAAACUAAAAAUAAAAAAUGAACAGUGUCCAACACCUUGAAAGCAUUCCGCAUGACUGAACGAUCACUGUUACGUGAUUACCAACAUGACGACCCCACUUCUCUUGGCCAAACUGAGUUCUCUUCUCUUGUAAAAACUUCUGCAUAUGAAGUCACCCAUUCCAUUUGACUCUUUAGCCCUCAUCCUGGCAUUCAAGGGCAUGGACGACUCAACCCCACUCUCUAGCCAGCCUGACCUCUCCAUUCCCUUCUCUGGCGUAGAGGCCACUCCCACCACCUGCCCUUACCCCCUGCCCACUUUUGUCAGCCUGUACUGUGUUGAAGCUCCCAGGAGAGACAACUGCAGUCAUCACUUUCCACUGUGUUCAGUGAUGUCAGUUCGGCCCAGCUGGAGGUACUCACAUCAUGGAAACAGACCAUCAGAUUUGGUGUGUGUGUGUUUUAUUUUGCUUUUUCAGAGAGCCAGCUGUUAAACACUAGCCAACACCCCAUUGAUGCUGUUCCUUCUACCUGAAACACCUCGCAUUGCCGGUGAGCUCUAAAGACAAAAGGACCUGGGUCUGCAUUUCCCAAAGGCAAGACUCUGGUAUCACCUGCAUAUUAUUUUCCCAUAUUUGAGCACCACUGCCUUUUGCAUUAUUUACUUAGCAGUUUUGCUCCUGUCAACUCACUUUUUUAAAACUAAACUUAUUUUAAAAAGAAAAGUUUUGGCCGGGAGCGGUGGCUCAUGCCUGUAAUCCCAGCACUUUGGGAGGCCGAGGUGGGCAGAUCACCUGAGGUCGGGAGUUCGAGACCAGCCUGACCAACAUGGAGAAACUCCGUCUCUACUAAAAAUACAAAAUUAGCUGGGCGUGGUGGCGCAUGCCUGUAAUCCUAGCUACUCGGGAGGCUGUGGCAGGAGAAUUGCUUGAACCCAGGAGGCGGGGGUUGCAGUGAGUCGAGAUCGCCCCAUUGUACUCCAGCCUGGGGAACAAGAACGAAACUCCGUCUC

Taxonomic tree

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Publications