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Homo sapiens (human) AFDN divergent transcript (AFDN-DT) URS000075BCEE_9606

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AFDN-DT: AFDN-DT is a long non-coding RNA (lncRNA) that is repressed in gastric cancer (GC) and functions as a tumor suppressor by inhibiting cell growth and metastasis through the transcriptional repression of genes involved in metastasis [PMC8438305]. Its tumor suppressive role in GC has been demonstrated, and it has been identified as a potential prognostic marker for GC [PMC8438305]. The expression levels of AFDN-DT, along with other lncRNAs, have been found to be negatively correlated with certain microRNAs in GC [PMC8973920]. The downregulation of AFDN-DT in GC has been attributed to the hypermethylation of its promoter [PMC9270757]. A risk model for GC has been developed, which includes AFDN-DT as one of the risk factors [PMC9843343]. In this model, AFDN-DT is associated with an increased risk of GC [PMC9843343]. The expression levels of the 11 lncRNAs included in the risk model showed different enrichment patterns between high-risk and low-risk groups, with AFDN-DT being relatively more highly expressed in the high-risk group [PMC9843343]. LncRNAs have been found to play important roles in cancer progression, including GC [PMC7667163].

Genome locations

Gene Ontology annotations

Sequence

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GCUCCACUAGGUGCUGCUGCCGCGGCCGCCAGGGAGGGAGGUGUCGGAGGGCGGGCCCCGCGCGGUGCUAGGGUUCCGUCUGGACUGGCGGUGGUGGGUCCCAACCGGCGGUACCGGGUUCCUUCCCGACCAGCGGUGCUAGGUUCGGUUCGGACGCGCGCUGCUGGAUCUAAAUGGGCAGUGCUGGGUCCGAUGGGUGGUGCUGUGUUGGGUCCGGACGCGCGGUGCAGAGUCCGGACGGGCGGUGCUGGAUCCAAAUGGGCGGUGCUGGAUCUGGACGGGCGGUGAUGGGUCCGAUGGGCGGUGCUAUGUUCGGUUCGGACGGGCGGUGCUAGGUCUAAAUGGGCGCUGCUGGGUCCGAUGGGCGGUGCUGCGUUCGGUCCGGACGGGCGGGGACGGGCGGUGCUGGGUCCAAAUGGGUGGUGAUGGAUCUGUGGACGGGCGGUGCUGGUUCCAGACGGGCGGUGCUGGGUCCAGACGGGCGGUGGGUCCGAUGGGCGGUGCUAGGUUCGGUUCGGAUGGGUGGUGCUAGGUCUAAAUGGGCGGCGCCGGAUCCGAUGGGCGGUGCUGGGUUCGGUCCGGACUGGCGGGUCCGGGUCUGGACGGGCGGUGCUGGAUCCAAAUGGGGGUGCAGUGCUGGAUCUGGACGGGCGGUGCUGGGUCCGAACGGGCGAUGGGUCCCAUGGGCGGUGCUAGGUUCGGUUCGGACUGGCGGUGCUGGGUCUAAAUGGGCGGCGCUGGGUCCGAUGGGUGGUACUGGGUCCGGACGGGCGGUUCUGGGUCUGGACGGGCGGUGCAGUAUCCAAAUGGGCGCUGCUGGGUCCGGACGGGCGGUGCUAGGUUCGGUCCGGACGGGUGGUGCUGGGUCUAAAUGGGCGGUGCUAGGCUCAGCAGGGGACCGGUGGGCGUGGCGGCACAGGUACGGAGCGCAGGGCCGGUGGAGCGCCCUCUCCGAAGGGCCCUGCGCUCCCCGCGCUCGCUGCUCCUCCUGCCCGCGCAUUGCCCCGGGGCUGCUGCGUGUUUCUUCCAGGGUGAUUCCUUUCCGCUGGGUCACUUCAAAGCCGACCUUUUCAAGCUGUUUUCUUCCGCGGAGGACACGUUGUUAGGCUUUGUGUGCAUUUCAAGGGUCAUGUUUUCUGAACCGCGCUCUGCCGCUCUUGGGGUGUUCGAGCCCCCACACUGCUGUGCGGUGUUCCUCUCACAGAGUGAGGUUGGAGGGUCCCACUCCCUUUGUGUGUCUCCUUAGAAAACGCCUCUUCUCUCAGACACAUCGUUAUCUGCCAAUUCUUCGCAGACGUAGAGAACGGACUGCAGAGUUAAUAAACGUCGAGGGGAAGCUUUGAUGCGCCCCAUUUGGCCCUGAGAGAUGCCACGUGAUCGUCAUUUUAAAUCCUUUCCUGGGCUUCCCGAUGGACUCGAGUUUUUACUAUGUGAGCAUCCCGGUGCCUGCACAGCAAGGACUCUCAUUGGGUUCCACACGUGCUGCGCAGAUCCCUGACGCAGCGUUCACUGAACCUCAACUGCAGGAGCUUCAUUCCUGAGGACGCUGUUACCAAGAAUGACUUGCCUCUUGAAGAAUGAGUUUGCAAAGCCGGCAGUUAGAUUGCUGAUGUCCAAAGUAAGUAUGUGUAGCAUCACUAAAGAGAAAAUUCAGGAUUCCUGGAAAACAGUUAUGGGCUCUCUGCAGUGUUAUUUUUGUAAUAAAAAACAUAUAGCAUAUGUGAAAUACCUACUGGGUGAUGCAGGACACAUAGAAGGCUCGAAAUUAAUGUGAAUCAUUCUCGUUUUUCUGACUGUCAUUAAAAGUCCCCAUUUGUAUUAUGUAUGAGUGGUAUAUCAAUAUCUAAACUACACUUUAUUGUAGGUCCCAACCAACAUUAGUUUAUUGACAAAUGUUUAAGAGCAGCCAAAAAUUCAUAGAAUACCUAUGAUUCUUAAAUCAUGAACACUCCCAUAACUGGUAUAUGUUUAGGACAUGAAAAUUUCCAGGCUGACAAAUAAUUUCGCUGUCAUCGGUCAAGACUCCAGGAUGAUAUUCUGAGCCAUAUGUUAAUUUUGAUAACCACCUAGAACAAUAAAAGGUAAACAUGCUACCAUCUUCUAUUCUCAUUGCACCACUGGAUUCUGGUACAUCUAAAAAUUGUACUUAAAUGAUAUCCAAGAAAUGCUGUAAAAAACAAAAUAGGGCCGGGCGCAGUGGCUCACACCUGUAAUCCCAGCAUUUUGGGAGGCCAAGGCGGGCAGAUCACGAGGUCAGGAGAUCAAGACCAUCCUGGCUAACACGGUGAAACCCCGUCUCUACUAAAAAUAC

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Publications