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hsa-mir-645: Hsa-mir-645 is a significantly downregulated miRNA [PMC7292968]. It is one of the miRNAs that negatively regulate four specific genes [PMC9650865]. Hsa-mir-645 is predicted to be a "Moderate Target" of COL4A4 [PMC9498445]. It has the potential to regulate the post-transcriptional level of hub CORGs in COVID-19 and MI [PMC10067640]. Hsa-mir-645 is downregulated in COVID-19 and MI [PMC6942769]. It is significantly associated with rs11089328 (DGCR8) in differential tissue expression under the dominant genotype [PMC4841949]. Hsa-mir-645 was not profiled in certain signatures, including signatures D, C, CB [PMC4519802]. The seed sequence of hsa-mir-645 was identified within the endo-siRNA derived from RMRP [PMC3676784]. However, hsa-mir-645 was not detected in certain cell types, unlike hsa-miR-1224-5p which was detected in all cell types [PMC3676784].
References:
[PMC7292968]
[PMC9650865]
[PMC9498445]
[PMC10067640]
[PMC6942769]
[PMC4841949]
[PM4519802]
[PM3676784]
Genome locations
Gene Ontology annotations
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