v27

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Homo sapiens (human) ZEB1 antisense RNA 1 (ZEB1-AS1) URS000075AC83_9606

  • 2,232 nucleotides
  • 2 databases (HUGO Gene Nomenclature Committee, RefSeq)
  • Found in 1 other species
  • lncRNA
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zeb1-as1: ZEB1-AS1, a long non-coding RNA (lncRNA) located near the ZEB1 gene, functions as an oncogenic regulator in various cancers, including glioma, colorectal, and gastric cancers [PMC6203088]. It has been implicated in the regulation of epithelial-mesenchymal transition (EMT) as its overexpression in C33A cells reduces E-cadherin levels while increasing N-cadherin and Vimentin [PMC6203088]. ZEB1-AS1 expression is significantly higher in melanoma samples with BRAF or RAS mutations compared to Triple Wild-Type groups [PMC6683136], and its overexpression is associated with increased proliferation and progression of glioma cells [PMC5037710]. Furthermore, ZEB1-AS1 has been shown to interact with various molecular partners such as LRPPRC [PMC6477043], miR-590-5p [PMC8574104], and miR-23a in OSCC cells [PMC8057792], indicating its role in complex regulatory networks. It also contributes to cancer progression by inhibiting tumor suppressor miRNAs like miR200c and activating oncogenes such as ZEB1 [PMC7103072]. Studies have also demonstrated that knockdown of ZEB1-AS1 can suppress cancer cell proliferation and migration, suggesting a potential therapeutic target for cancers like liver cancer and bladder cancer [PMC6447761; PMC6397446].

mRNA interactions total

Genome locations

Gene Ontology annotations

Sequence

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CUUACACCUAGAGGCUCUCGCUCUACGGCCGGAACCUUGUUGCUAGGGACCGGGCGGUUUGCGGCAACCGUGGGCACUGCUGAAUUUGAAUUGAGGGGCGAGGGAAAAGUUUUCCUCAGGUGUGGUGGGGAGAGGGAGGCGGAUGCCGGGAAACCGUAGGGACGCGGUCAGAAAGGCGACGGGCUGUCGGAGUUGGAAAGGGACGCCUGGUUUCCCCCCAAGCGAACCGGGAUGGGAAGUGACUUCAAUGAGAUUGAACUUCAGCUGGAUUGAAAGAGAGGCUAGAAGUUCCGCUUGCCAGCAGCCUCCUUAGUAGAGCGGAAUGAGUAAUACCCACACGGUGCUUGUCUCACUUCCCCAUCCGCACCCGGCCCUCACCUGCUGUCACCUCGGCCUCCCACACCCGGUCCGCGCUCCCCGCCCUCUUCCUCGCGUAGAACCGUGGGAUCCUAGGUGGCAGGACUCAGAGCUAAGGUAUCCACAGGCCAUGAAUUCCUUCCUAAAUGAGCGGUCAUCGCCGUGCAGGACCUUAAGGCAAGAAGCAUCGGCUGACAGAUGUGAUCUCUGAACCUGAUAGAUUGCUGAUUUUAUCUUAUUUUAUCCUUGACUUGGUACAAGUUUUGGGAUUUCUGAAAAGACCAUACAGAUAACCACAAAUAUCAAGAAAGUCGUCUUCAGUAUUAAGUAGAAUUUAGAUUUAGGUUUCCUUCCUGCUUCCCACCUCCUUCGAAUAAGGAAACGUCUUUGGGACCAACUUUAUGGAAUAAAUAAGCUGAGCUGUAUUUCAAGUAAUAUAGUUAUAAAUUAACAAUGUAGCAGUUAUUGAUAGAGAAAUUGAGAAAACUGAAACGUGACCGGAGUAUUGGAAAUAACGUAGUACAUCACCUAGCACAAUGACACAUAGUAGGUGCUCAAUAAAUUUAUGCUUAUAAUUUUUGUCACUUCUAUGGCAGGAUUUUUUUAUUAGGUUAAAAUUAUCUUUUAAACACCUUCCGGAAUUUUAGAAUAUUCAUUAAUAAUGUCUUCAAACCUUUCAACUGAAAUAAAUUUACAGCUGAAGUCUGAUGAUUUAAAGUUAGAAAGUUUAAUCUUGAAUAUAAAUGAACAUUUUCUCUCCCACAUUUUCUUGGGCAUUUUGAGAAGUAAAUGCGUUAUUUAUUGGUCCAUGAAAUGUGACUGUAAAUAUUCUUUGCUAUACAUUAUGUCUAUAUAUCUGCAUUCAUCCUCAAUGCCAAAACUAGAAUCAUUAGUCUUAAUGAUCAUUUUAAGUACAGGCAGUCCUCGCUUUCCUUGAUACCAUGUUAACCGAAACUUGUGUAUGUCAACACGGUGUCCUUGCUUUGCUUGGUUAAGUGUGAGUUCUUCCUCCCUUUUUUUAAGAGUUGUACAAUGUUUUUCAGUCGCCUACCGAAUCAGGUCAUAGACUAUGGAAUUGACCCCACCCCACCAACAUUUUUACAGCUACCCUGAUUUCUGACCAGAAAGGAAAAAAAAACUUUCCAGCUCUAUCACACAUUUUACCUACUCUUAAACUUAGGAGGUAUUACAAAUAGCAUUUUCUCAUGUUCUCUUUCUGGCCUGUACCUCCCUGCUAAGCUUCCUUCAGUGUUCAUCCUCACCUCAUAGAGAGAUGAAGUGAAGAGACAAACAGAAGUCAUUUUCUUCCUUACUUUAGUGGUUUCUGGUUUAGUUAGUUUGGGCCAAACUGUGGACAAGUACCUUUUCAGGUAACUUUUUUUUCUUAUUUCUAUGUCCUCAACACCUAGUGGAGUACGUAGCCAAUAGUAGAUGCUUAAUAAACAUUUCUUAAAUUAAUAUUGUUGACCUUUUCUGACCCUGUUCUUGACAGUAAGGUACAUAAUCUGCCUUCAUCCCUUUAGUCCUUAGGAACAGAUAAAGUCAUGGAUAUGAAAGUGAUCACUGUCAUUAAUAUCCACAUUAAAAUUGCUCUUGAUUUUAGUUUCUCCAUAAUCAUUUUCCCUAAACAAUGAACUCUGUUCACCUUUUUUUUUAAAAUAUGCACAGUGAAUAUUACUGGUAGCCCAAAUCUUCUAACAUAAAAUUUCCAUUUUGUAAAAGCUUCUGAUAAGCAUAUAUGUUAUGAAUUGAAUGUUUGAUUAUUAUACUUUAAUAUUCUUGAAAAUAUUGAUACCUGGACUGGAAAGAAAACAGACAAAAGUAAAUCUCAGAAUAAAUUACUGCUUUAAACAUGAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Relationships

Molecular Relationships