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Homo sapiens (human) ZEB1 antisense RNA 1 (ZEB1-AS1) URS000075AC83_9606

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ZEB1-AS1: ZEB1-AS1 is a long non-coding RNA (lncRNA) that has been implicated in various cancers, including melanoma, glioma, colorectal cancer, gastric cancer, liver cancer, bladder cancer, prostate cancer, osteosarcoma, and oral squamous cell carcinoma (OSCC) [PMC6203088] [PMC6683136] [PMC9821083] [PMC8645903] [PMC7435023] [PMC5037710]. It has been shown that ZEB1-AS1 is upregulated in melanoma samples carrying BRAF or RAS mutations and is associated with the progression of the disease [PMC6683136]. In glioma cells, ZEB1-AS1 plays a vital role in regulating proliferation and progression [PMC5037710]. In liver cancer cells, ZEB1-AS1 is required for cell proliferation [PMC6447761]. In bladder cancer cells, ZEB1-AS1 promotes cell migration and invasion [PMC6397446]. Additionally, ZEB1-AS1 has been implicated in renal fibrosis suppression and immune stimulation pathways [PMC9406440] [PMC9623420]. Mechanistically, ZEB1-AS1 can act as a sponge for various microRNAs (miRNAs) to regulate gene expression. For example, it can inhibit tumor suppressor miR200c in prostate cancer cells and miR23a in OSCC cells. It can also modulate the expression of miR204-5p/miR610/miR149-3p in colorectal cancer cells. Furthermore,ZEB 11 AS 11 can recruit histone acetyltransferase p300 to the promoter region of ZEB 11 to promote osteosarcoma proliferation and migration. Overall,ZEB 11 AS 11 plays an oncogenic role in various cancers and has the potential to serve as a biomarker for cancer diagnosis and prognosis [PMC7103072] [PMC8057792] [PMC7359398] [PMC6364449] [PMC9224338].

Genome locations

Gene Ontology annotations

Sequence

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CUUACACCUAGAGGCUCUCGCUCUACGGCCGGAACCUUGUUGCUAGGGACCGGGCGGUUUGCGGCAACCGUGGGCACUGCUGAAUUUGAAUUGAGGGGCGAGGGAAAAGUUUUCCUCAGGUGUGGUGGGGAGAGGGAGGCGGAUGCCGGGAAACCGUAGGGACGCGGUCAGAAAGGCGACGGGCUGUCGGAGUUGGAAAGGGACGCCUGGUUUCCCCCCAAGCGAACCGGGAUGGGAAGUGACUUCAAUGAGAUUGAACUUCAGCUGGAUUGAAAGAGAGGCUAGAAGUUCCGCUUGCCAGCAGCCUCCUUAGUAGAGCGGAAUGAGUAAUACCCACACGGUGCUUGUCUCACUUCCCCAUCCGCACCCGGCCCUCACCUGCUGUCACCUCGGCCUCCCACACCCGGUCCGCGCUCCCCGCCCUCUUCCUCGCGUAGAACCGUGGGAUCCUAGGUGGCAGGACUCAGAGCUAAGGUAUCCACAGGCCAUGAAUUCCUUCCUAAAUGAGCGGUCAUCGCCGUGCAGGACCUUAAGGCAAGAAGCAUCGGCUGACAGAUGUGAUCUCUGAACCUGAUAGAUUGCUGAUUUUAUCUUAUUUUAUCCUUGACUUGGUACAAGUUUUGGGAUUUCUGAAAAGACCAUACAGAUAACCACAAAUAUCAAGAAAGUCGUCUUCAGUAUUAAGUAGAAUUUAGAUUUAGGUUUCCUUCCUGCUUCCCACCUCCUUCGAAUAAGGAAACGUCUUUGGGACCAACUUUAUGGAAUAAAUAAGCUGAGCUGUAUUUCAAGUAAUAUAGUUAUAAAUUAACAAUGUAGCAGUUAUUGAUAGAGAAAUUGAGAAAACUGAAACGUGACCGGAGUAUUGGAAAUAACGUAGUACAUCACCUAGCACAAUGACACAUAGUAGGUGCUCAAUAAAUUUAUGCUUAUAAUUUUUGUCACUUCUAUGGCAGGAUUUUUUUAUUAGGUUAAAAUUAUCUUUUAAACACCUUCCGGAAUUUUAGAAUAUUCAUUAAUAAUGUCUUCAAACCUUUCAACUGAAAUAAAUUUACAGCUGAAGUCUGAUGAUUUAAAGUUAGAAAGUUUAAUCUUGAAUAUAAAUGAACAUUUUCUCUCCCACAUUUUCUUGGGCAUUUUGAGAAGUAAAUGCGUUAUUUAUUGGUCCAUGAAAUGUGACUGUAAAUAUUCUUUGCUAUACAUUAUGUCUAUAUAUCUGCAUUCAUCCUCAAUGCCAAAACUAGAAUCAUUAGUCUUAAUGAUCAUUUUAAGUACAGGCAGUCCUCGCUUUCCUUGAUACCAUGUUAACCGAAACUUGUGUAUGUCAACACGGUGUCCUUGCUUUGCUUGGUUAAGUGUGAGUUCUUCCUCCCUUUUUUUAAGAGUUGUACAAUGUUUUUCAGUCGCCUACCGAAUCAGGUCAUAGACUAUGGAAUUGACCCCACCCCACCAACAUUUUUACAGCUACCCUGAUUUCUGACCAGAAAGGAAAAAAAAACUUUCCAGCUCUAUCACACAUUUUACCUACUCUUAAACUUAGGAGGUAUUACAAAUAGCAUUUUCUCAUGUUCUCUUUCUGGCCUGUACCUCCCUGCUAAGCUUCCUUCAGUGUUCAUCCUCACCUCAUAGAGAGAUGAAGUGAAGAGACAAACAGAAGUCAUUUUCUUCCUUACUUUAGUGGUUUCUGGUUUAGUUAGUUUGGGCCAAACUGUGGACAAGUACCUUUUCAGGUAACUUUUUUUUCUUAUUUCUAUGUCCUCAACACCUAGUGGAGUACGUAGCCAAUAGUAGAUGCUUAAUAAACAUUUCUUAAAUUAAUAUUGUUGACCUUUUCUGACCCUGUUCUUGACAGUAAGGUACAUAAUCUGCCUUCAUCCCUUUAGUCCUUAGGAACAGAUAAAGUCAUGGAUAUGAAAGUGAUCACUGUCAUUAAUAUCCACAUUAAAAUUGCUCUUGAUUUUAGUUUCUCCAUAAUCAUUUUCCCUAAACAAUGAACUCUGUUCACCUUUUUUUUUAAAAUAUGCACAGUGAAUAUUACUGGUAGCCCAAAUCUUCUAACAUAAAAUUUCCAUUUUGUAAAAGCUUCUGAUAAGCAUAUAUGUUAUGAAUUGAAUGUUUGAUUAUUAUACUUUAAUAUUCUUGAAAAUAUUGAUACCUGGACUGGAAAGAAAACAGACAAAAGUAAAUCUCAGAAUAAAUUACUGCUUUAAACAUGAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications