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hsa-mir-637: Hsa-mir-637 is a microRNA (miRNA) that has been reported to regulate relevant IRD-causative genes in response to oxidative stress injuries in retinal pigment epithelial (RPE) cells [PMC7222416]. It has been identified as one of the significantly differentially expressed miRNAs in RPE cells challenged with oxidizing compounds [PMC5865992]. Hsa-mir-637 mimics and inhibitors were used in a study to examine its molecular mechanism in regulating the malignant behaviors of hepatocellular carcinoma (HCC) [PMC7137343]. Bioinformatics analysis identified hsa-mir-637 as one of the potential target miRNAs for hsa_circ_0039053, a circular RNA involved in HCC [PMC7591988]. The binding position of hsa-mir-637 within a segment was found to be highly conserved among different influenza virus strains [PMC3521223]. Downregulation of hsa-mir-637 has also been observed in HCC samples, along with other miRNAs [PMC7444729]. Hsa-mir-637 has been associated with drug resistance, while other miRNAs like hsa-let-7d-5p and hsa-miR-18a-5p have been associated with drug sensitivity [PMC6504094]. It has also been identified as a potential regulator within a network of miRNAs that impact gene expression [PMC5569676]. Additionally, hsa-miR-328-3p, among other miRNAs, has been reported as diagnostic or prognostic biomarkers for glioma [PMC9983174]. The binding of hsa-mir-637 to the 3' untranslated region of ATP6V0A1 mRNA is disrupted by a polymorphism, leading to impaired secretion and function related to Chromogranin A (CHGA)/catestatin [PMC4554020]. Furthermore, hsa-mir-637 has been found to downregulate STAT3 activity in hepatocellular carcinoma cells [PMC6504094].
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