SNORD113-1: SNORD113-1 is a small nucleolar RNA (snoRNA) that has been studied in relation to its effects on MEK and ERK1/2 phosphorylation. Overexpression of SNORD113-1 was found to significantly decrease phosphorylation of MEK and ERK1/2, while not significantly altering the expression of total ERK and total MEK [PMC4169825]. SNORD113-1 has been identified as a tumor suppressor in hepatocellular carcinoma (HCC) patients with overexpression of ACSL4 [PMC7599548]. In HepG2 cells, treatment with 5 μmol/L 5-Ad for 48 hours resulted in a 2.06-fold increase in SNORD113-1 expression levels compared to vehicle-treated cells [PMC4169825]. The SNORD113-1 gene is located on chromosome 14q32 within an intron of the small nucleolar RNA host gene 23 (SNHG23, Gene ID: 100507242), along with several miRNAs and other C/D snoRNAs [PMC4169825]. Overall, these findings suggest that SNORD113-1 plays a role in regulating the phosphorylation of MEK and ERK1/2, as well as functioning as a tumor suppressor in HCC patients with overexpression of ACSL4.