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Homo sapiens (human) PCGEM1 prostate-specific transcript URS00007479E9_9606

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PCGEM1: PCGEM1 is an exosomal long non-coding RNA (lncRNA) that has been found to differ between patients with osteoarthritis (OA) and healthy individuals, as well as between late and early stages of OA [PMC9588998]. In various tumors, PCGEM1 has been shown to promote tumor growth in in vivo experiments of ovarian cancer (OC), endometrial cancer (EC), and glioma [PMC8898824]. PCGEM1 overexpression has also been found to contribute to the suppression of inflammation in asthmatic mice following treatment with montelukast sodium [PMC7296716]. The enrichment of PCGEM1 has been shown to be dependent on MEF2, as demonstrated through chromatin immunoprecipitation (ChIP) analysis [PMC6059670]. PCGEM1 is involved in the regulation of metabolic genes as a coactivator of the androgen receptor [PMC8308086]. The interaction between p54/nrb and the PCGEM1 promoter is abolished in the presence of DIM [PMC5041109]. Androgen deprivation induces PCGEM1 expression and causes its subcellular redistribution [PMC4941255]. In endometrial carcinoma, PCGEM1 enhances cell proliferation and apoptosis by targeting STAT3 through downregulation of miR-129 [PMC10012497]. Knockdown of PCGEM1 leads to a significant reduction in prostate cancer cell proliferation, while overexpression of miR-145 also contributes to this effect [PMC4173053]. PCGEM1 promotes CDK6 expression by inhibiting miR-539-5p [PMC7950308]. PCGEM1 is mostly distributed in the cytoplasm, indicating that it primarily functions at the posttranscriptional level. It has been implicated in various cancers, including prostate cancer (PCa), non-small cell lung cancer (NSCLC), and osteosarcoma (OS) [PMC9546849] [PMC10012497] [PMC10102293]. However, there is evidence suggesting that PCGEM1 may not be a reliable prognostic marker for PCa [PMC5945524]. PCGEM1 has been found to cooperate with other lncRNAs, such as PRNCR1, in androgen receptor-targeted gene transcription [PMC8898824]. It has also been identified as a possible target for prostate cancer therapy [PMC4584070]. The comprehensive functions of PCGEM1 and its associated molecules in various tumors are listed in Table 2 [PMC8898824]. Overall, these findings suggest that PCGEM1 may play a crucial role in the early stages of primary prostate cancer initiation [PMC4342943].

Genome locations

Gene Ontology annotations

Sequence

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AAGGCACUCUGGCACCCAGUUUUGGAACUGCAGUUUUAAAAGUCAUAAAUUGAAUGAAAAUGAUAGCAAAGGUGGAGGUUUUUAAAGAGCUAUUUAUAGGUCCCUGGACAGCAUCUUUUUUCAAUUAGGCAGCAACCUUUUUGCCCUAUGCCGUAACCUGUGUCUGCAACUUCCUCUAAUUGGGAAAUAGUUAAGCAGAUUCAUAGAGCUGAAUGAUAAAAUUGUACUACGAGAUGCACUGGGACUCAACGUGACCUUAUCAAGUGAGCAGGCUUGGUGCAUUUGACACUUCAUGAUAUCAGCCAAAGUGGAACUAAAAACAGCUCCUGGAAGAGGACUAUGACAUCAUCAGGUUGGGAGUCUCCAGGGACAGCGGACCCUUUGGAAAAGGACUAGAAAGUGUGAAAUCUAUUAGUCUUCGAUAUGAAAUUCUCUGUCUCUGUAAAAGCAUUUCAUAUUUACAAGACACAGGCCUACUCCUAGGGCAGCAAAAAGUGGCAACAGGCAAGCAGAGGGAAAAGAGAUCAUGAGGCAUUUCAGAGUGCACUGUCUUUUCAUAUAUUUCUCAAUGCCGUAUGUUUGGUUUUAUUUUGGCCAAGCAUAACAAUCUGCUCAAGAAAAAAAAAUCUGGAGAAAACAAAGGUGCCUUUGCCAAUGUUAUGUUUCUUUUUGACAAGCCCUGAGAUUUCUGAGGGGAAUUCACAUAAAUGGGAUCAGGUCAUUCAUUUACGUUGUGUGCAAAUAUGAUUUAAAGAUACAACCUUUGCAGAGAGCAUGCUUUCCUAAGGGUAGGCACGUGGAGGACUAAGGGUAAAGCAUUCUUCAAGAUCAGUUAAUCAAGAAAGGUGCUCUUUGCAUUCUGAAAUGCCCUUGUUGCAAAUAUUGGUUAUAUUGAUUAAAUUUACACUUAAUGGAAACAACCUUUAACUUACAGAUGAACAAACCCACAAAAGCAAAAAAUCAAAAGCCCUACCUAUGAUUUCAUAUUUUCUGUGUAACUGGAUUAAAGGAUUCCUGCUUGCUUUUGGGCAUAAAUGAUAAUGGAAUAUUUCCAGGUAUUGUUUAAAAUGAGGGCCCAUCUACAAAUUCUUAGCAAUACUUUGGAUAAUUCUAAAAUUCAGCUGGACAUUGUCUAAUUGUUUUUUAUAUACAUCUUUGCUAGAAUUUCAAAUUUUAAGUAUGUGAAUUUAGUUAAUUAGCUGUGCUGAUCAAUUCAAAAACAUUACUUUCCUAAAUUUUAGACUAUGAAGGUCAUAAAUUCAACAAAUAUAUCUACACAUACAAUUAUAGAUUGUUUUUCAUUAUAAUGUCUUCAUCUUAACAGAAUUGUCUUUGUGAUUGUUUUUAGAAAACUGAGAGUUUUAAUUCAUAAUUACUUGAUCAAAAAAUUGUGGGAACAAUCCAGCAUUAAUUGUAUGUGAUUGUUUUUAUGUACAUAAGGAGUCUUAAGCUUGGUGCCUUGAAGUCUUUUGUACUUAGUCCCAUGUUUAAAAUUACUACUUUAUAUCUAAAGCAUUUAUGUUUUUCAAUUCAAUUUACAUGAUGCUAAUUAUGGCAAUUAUAACAAAUAUUAAAGAUUUCGAAAUAGAAAAAAAAAAAAAAA

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Publications