SNORD14D: SNORD14D is a C/D box small nucleolar RNA (snoRNA) that has been shown to be involved in leukemia development in certain models [PMC6489307]. It is one of the snoRNAs that are cyclically expressed, along with Snord35b and Snord57 [PMC5454292]. SNORD14D and Snord57 are known to modify 18S rRNA, and their expression profiles show contrasting phase [PMC5454292]. SNORD14D is highly expressed compared to its host gene Hspa8 at certain times of the day [PMC5454292]. SNORD14D, along with other snoRNAs, exhibits cyclical expression patterns in mammalian liver [PMC5454292]. It has been demonstrated that SNORD14D and SNORD35A are necessary for proper leukemogenesis and are upregulated by leukemia oncogenes [PMC5654102]. Knockdown of SNORD14D or SNORD35A suppresses the clonogenic potential of leukemia cells in vitro and delays leukemogenesis in vivo [PMC6629867]. In acute myeloid leukemia (AML), SNORD14D is required for AML1-ETO-mediated leukemogenesis [PMC8677010]. In polycystic ovary syndrome (PCOS), the expression of SNORD14D is upregulated compared to controls [PMC9156844]. Deletion or depletion of SNORD14D impairs clonogenic growth and reduces cell size and protein synthesis rate [PMC7114786][PMC9413531][PM7114786][PM8629011][PM4460846][PM4460846][PM7093170][PM8125340].