snord114-22: SNORD114-22 is a small nucleolar RNA (snoRNA) involved in the regulatory processes of methylation and pseudouridylation within cells [PMC6767209]. In the context of adrenocortical carcinoma (ACC) samples, SNORD114-22 was identified as one of the four snoRNAs that were significantly downregulated [PMC5607708]. This snoRNA, along with others, has been found to have a strong positive correlation with T cell-mediated cytotoxicity in tumors, as indicated by granzyme levels [PMC9149963]. In human periodontal ligament stem cells modified to overexpress the µ-opioid receptor (hPDLSCs-MOR), SNORD114-22 is one of the genes uniquely expressed compared to control cells (hPDLSCs-CTR), suggesting a role in cellular differentiation or response to environmental changes [PMC6767209]. Furthermore, SNORD114-22 has been associated with an upregulation at the DLK1-DIO3 genomic locus, which is known for its involvement in growth and development [PMC9267054]. Lastly, research on skin warts has revealed that SNORD114-22 is hypomethylated compared to normal skin tissue, which could have implications for its expression and function in epidermal biology or pathology [PMC7783806].