SNORD64: SNORD64 is a C/D box small nucleolar RNA (snoRNA) gene located in the PWS/AS imprinted domain [PMC3077502]. It is one of the snoRNAs expressed in this domain, along with SNORD107, SNORD108, SNORD109A, and SNORD109B [PMC3319576]. These snoRNAs are involved in various biological processes and have been found to be upregulated in certain diseases, such as ERG-related BCP-ALL [PMC9219770]. Studies have shown that the expression of SNORD64 and other protein-coding genes at the PWS locus is not perturbed [PMC8037846]. Additionally, chimeric mice with a 5′LoxP cassette inserted downstream from SNORD64 did not exhibit discernible phenotypic differences [PMC4742849]. The snoRNA genes located within the large SNURF-SNRPN transcripts are present not only as single copies but also in two snoRNA gene clusters (SNORD115 and SNORD116) [PMC5073158]. In PWS INS-1 lines with complete loss of expression, including Snurf, Snrpn, Ipw, Mkrn3, all four snoRNAs (Snord116, Snord115, Snord107 and SNORD64), miRNA (Mir344 isoforms), and duplicated U1-Snurf sequences are affected [PMC10138222]. These findings highlight the importance of snoRNAs like SNORD64 in various biological processes and disease states.