SNORA14: SNORA14 is a small nucleolar RNA (snoRNA) that has been studied in Xenopus tropicalis and humans. In Xenopus tropicalis, SNORA14, along with SNORA28 and SCARNA4, is found within introns and can modify ribosomal RNA (rRNA) [PMC6298559]. In a bioinformatics analysis of vertebrate snoRNAs, amphibian and zebrafish SNORA14 were identified as potential guide RNAs for pseudouridylation of 18S rRNA at a specific position [PMC6298559]. When Xenopus SNORA14 was expressed in HeLa cells, pseudouridylation of human 18S rRNA at that position was observed [PMC6298559]. In the context of the lncRNA-target regulatory network, upregulated MSTRG.14719.6 was found to target genes encoding small nucleolar RNAs (SNORDs) and small nucleolar RNAs (SNORAs), including SNORA14 [PMC6123486]. The ribonucleoprotein DYSKERIN was found to bend the SNORA14 transcript in vivo, bringing two pseudouridylation loops close to each other [PMC4931010]. Despite its conservation, SNORA14 has lost its modification activity on rRNA at a highly conserved region [PMC6984369]. Interestingly, when expressed exogenously from a plasmid in Xenopus tropicalis, SNORA14 was able to modify corresponding positions in yeast as well [PMC6984369].