SNORD22: SNORD22 is a small nucleolar RNA (snoRNA) that has been analyzed in various studies. It was found to be present in circulating extracellular vesicles (EVs) from patients with pancreatic cancer (PC) and controls [PMC8200014]. In an OVA/PM10-treated model, the expression of SNORD22 was increased compared to the control [PMC7801812]. In Upf3a KO livers, SNORD22 RNA transcripts were mildly but significantly up-regulated [PMC10070813]. SNORD22 is hosted by the small nucleolar RNA host gene SNHG1, as reported by Mark et al in 1997 [PMC6912041]. Activation of p53 was found to repress the intracellular level of SNHG1, which subsequently reduced the level of snoRNAs including SNORD22 [PMC7154078]. Additionally, SNORD22 has been widely detected along with other snoRNAs such as SNORD26 and SNORA48 [PMC5669939]. In terms of function, some snoRNAs including U3 (SNORD3), U14A/B (SNORD14A/B), U17A/B (SNORA73A/B), U8 (SNORD118), and U22 (SNORD22) have been shown to coordinate pre-RNA folding by forming basepairing interactions with distant regions of the pre-rRNA transcript [PMC6600647]. Furthermore, DRVO normalization led to an equivalent abundance of certain genes including SNORD22 compared to CD normalization [PMC4891691]. References: - PMC8200014 - PMC7801812 - PMC10070813 - PMC6912041 - PMC7154078 - PMC5669939 - PMC6600647 - PMC4891691