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SNORD113-5: SNORD113-5 is a component of the DLK1-DIO3 cluster and is a small nucleolar RNA (snoRNA) [PMC5796982]. The expression levels of SNORD113-5, along with other cluster components such as DIO3, SNORD113-7, SNORD114-9, and miR-889, were analyzed using qPCR [PMC5796982]. The results showed that the expression levels of these components were inversely associated with their methylation levels [PMC5796982]. In tumor samples, hypomethylation of SNORD113-5 and other components correlated with high gene expression compared to non-tumoral tissue [PMC5796982]. In patients with HBV infection, lower expression levels of SNORD113-5 were observed compared to patients without HBV infection [PMC9454744]. Additionally, in post-therapeutic LACC samples compared to pre-therapeutic LACC samples, SNORD113-5 was found to be upregulated along with other snoRNAs such as SNORD116-4 and SNORD114-1 [PMC6900565]. Furthermore, several snoRNAs including SNORD114-3 and SNORD113-8 were identified as key regulators by co-expressing with more than 150 mRNAs [PMC6900565]. These findings suggest that the expression levels of SNORD113-5 are influenced by methylation status and can be altered in various disease conditions.
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